What is the principle behind low mean corpuscular volume?

In medicine, both the red blood cells and the white blood cells in the human body must be in a balanced state, otherwise it is easy to show symptoms of imbalance. Many people are often told during the refining process that their red blood cell volume is low. This symptom should be considered at any time. Whether the red blood cell volume is low or high, it is an abnormal manifestation of the individual's body.

Pathological variation

1. Elevated: seen in malnutrition-related megaloblastic anemia (malnutrition; malabsorption; post-gastrectomy, intestinal disease, parasitic diseases such as sparganosis; and pernicious anemia, mixed deficiency, folic acid, B12, cancer; genetic causes). Alcoholic cirrhosis, extrapancreatic insufficiency, acquired hemolytic anemia, hemorrhagic anemia after regeneration, and hypothyroidism.

2. Decreased: seen in microcytic hypochromic anemia (secondary anemia caused by cancer or infection; hyperferremia seen in sideroblastic anemia and lead poisoning and CO poisoning), systemic hemolytic anemia (thalassemia, hereditary spherocytosis, congenital pyruvate kinase deficiency).

Drug effects

1. Increase: Drugs that can cause megaloblastic anemia include barbiturates, luminal (folate metabolism disorder), doxorubicin, phenytoin sodium, phenacetin (occasionally), triamterene, estrogen, hypoglycemic agent (causing folic acid or vitB12 deficiency), furans, neomycin, isoniazid, cycloserine, aminobenzoic acid (inducing gastrointestinal absorption disorder), aminosalicylic acid, methotrexate, colchicine (accompanied by vitB12 deficiency). Among them, anticonvulsants increase the level by about 3%.

2. Decrease: Neocoumarol may cause microcytic hypochromic anemia.