How to treat stubborn ringworm

Stubborn psoriasis is particularly prone to recurrence. After the patient has recovered from the first treatment, if the diet is not well controlled and consolidated, it is particularly prone to a second attack. Stubborn psoriasis can appear on various parts of the skin of our body, making the patient feel particularly itchy at the site of onset. So how can stubborn psoriasis be treated effectively?

Refractory psoriasis is in contrast to "primary psoriasis" and "transient psoriasis". Compared with these two, refractory psoriasis is a secondary onset, or multiple onsets, with relevant clinical characteristics such as gradually increasing number of onsets, gradually prolonged relapse time, gradually shortened relapse interval, and gradually worsening of relapse lesions. In a large number of clinical surveys, the incidence of refractory psoriasis has exceeded 75%, and most patients have a history of secondary onset. However, the recurrence rate of patients with refractory psoriasis who have received traditional treatment is still as high as over 80%. Many patients have reported that psoriasis is a bit difficult to "deal with". The symptoms will be relieved after taking some medicine, but once the medicine is stopped, psoriasis will "come back" again. It can only treat the symptoms but not eliminate the root cause, which has become a major concern for many psoriasis patients.

Psoriasis is a common chronic inflammatory skin disease that is persistent and recurrent. An important characteristic of the pathophysiology of psoriasis is that the number of basal keratinocytes entering the proliferative pool is significantly increased compared to normal, and the cell proliferation is accelerated. The mitotic cycle is shortened from the normal 311 hours to 375 hours, and the epidermal transit time is also shortened from 28-56 days to 3-4 days. Because keratinocytes pass through the epidermis too quickly, they do not have time to fully mature, and incomplete keratinization appears histologically, and the granular layer disappears. The characteristics of the skin lesions are the initial appearance of erythematous papules, the epidermis is covered with layers of silvery-white scales, the skin is dry, desquamated and scabby. Some skin symptoms are connected into a piece, shaped like a map, while others are itchy, with pus and water discharge, and blood stains, which are horrible to the sight.

Psoriasis has obvious seasonality. For most patients, the condition worsens in spring and winter and improves in summer. The national total prevalence rate is 0.72‰, with more men than women, more in the north than in the south, and higher in cities than in rural areas. The age of first onset is mostly 20-39 years old for males and 15-39 years old for females. In the past decade, the incidence rate has tended to increase and occur earlier. It is generally believed that psoriasis is related to industrial pollution and working environment. It is prone to occur in exposed parts such as the head, limbs, chest, back, etc. Although it is not life-threatening, it cannot be cured for a long time, and it relapses and worsens year by year, causing desquamation, blood stasis, dryness and unbearable itching, which brings great pain to the patient's physical and mental health and seriously affects the quality of life! Especially for young boys and girls, they are ashamed to expose their skin, which directly affects their appearance and brings great negative impact on their study, work and making friends!

The pathological changes of psoriasis vulgaris are hyperkeratosis and parakeratosis of the epidermis. Small abscesses composed of neutrophils can be seen in the parakeratotic areas, which are called Munro's abscesses. The granular layer is significantly reduced or disappeared. Thickening of the stratum spinosum. The epidermal processes extend, and their lower ends widen and can coincide with the adjacent epidermal processes. The dermal papilla extends in a club-shaped shape, and the spinous layer above it becomes thinner. The capillaries in the nipple dilate and become congested, so Auspitz's sign appears clinically. Infiltration of lymphocytes and neutrophils can be seen around

The pathological changes of arthritis psoriasis are the same as those of psoriasis vulgaris mentioned above and will not be repeated here. The pathological changes of erythrodermic psoriasis are mainly obvious inflammatory reaction and significant edema in the upper dermis. Other features are basically similar to those of psoriasis vulgaris. The pathological changes of pustular psoriasis and acrodermatitis continua are characterized by the formation of larger pustules, namely Kogoj pustules, in the epidermis, mainly in the upper part of the epidermis. The pustules are mainly composed of neutrophils. Other changes are roughly the same as those of psoriasis vulgaris, but the incomplete keratinization and extension of epidermal protrusions are milder. The pathological changes of palmoplantar pustulosis are unilocular pustules in the epidermis, with a large number of neutrophils and a small number of monocytes in the pustules, and infiltration of lymphocytes, histiocytes and neutrophils in the superficial dermis.