What is the cause of hypertrophic cardiomyopathy?

When it comes to hypertrophic cardiomyopathy, we need to pay attention to scientific knowledge and understanding, because these diseases actually pose a relatively toxic threat to human health. Common causes include genetic factors, and endocrine disorders can also have an impact on it.

1. Causes

1. Genetics

Multiple people in a family may be affected, suggesting that it is related to genetics.

2. Endocrine disorders

Many patients with pheochromocytoma have coexisting hypertrophic cardiomyopathy. Intravenous infusion of large amounts of norepinephrine in humans can cause myocardial necrosis. Animal experiments have shown that intravenous infusion of catecholamines can cause myocardial hypertrophy. Therefore, some people believe that hypertrophic cardiomyopathy is caused by endocrine disorders.

2. Clinical manifestations

There are significant differences in the disease between men and women. Most symptoms appear between the ages of 30 and 40. As age increases, the symptoms become more obvious. The main symptoms include dyspnea, exertional dyspnea, severe orthopnea or paroxysmal nocturnal dyspnea. Angina pectoris: often typical angina pectoris, with onset after exertion. If the chest pain persists for a long time, sublingual nitroglycerin is not only ineffective but may also make the condition worse. Syncope and dizziness; often occur when tired. It is caused by a drop in blood pressure. When tachycardia or bradycardia occurs, it can also cause syncope and dizziness. Palpitations: The patient feels that the heart is beating strongly, especially when lying on the left side, which may be caused by arrhythmia or changes in heart function.

Treatment

Hypertrophic cardiomyopathy develops slowly and has a good prognosis, but it can cause sudden death due to arrhythmias. In daily life, you should pay attention to avoid overwork and excessive mental stress. Beta-blockers and propranolol can reduce myocardial contractility, alleviate left ventricular outflow tract obstruction, improve left ventricular wall compliance and left ventricular filling, and also have anti-arrhythmic effects.

Surgical treatment: If the pressure gradient is >60mmHg and drug treatment is ineffective, surgical treatment can be used. Hypertrophic muscle resection is possible. Patients with severe mitral regurgitation can undergo mitral valve replacement.