What are the dangers of nephrogenic diabetes insipidus

The occurrence of diabetes insipidus is basically a problem with the filtration and reabsorption of the glomeruli. If it is not treated for a long time, it is likely to cause further damage to the kidney function and the bladder will also be severely burdened.

complication

1. Bladder distension, ureteral dilatation, hydronephrosis and chronic renal failure. The reason for the complications of the above diseases is due to the long course of the disease and excessive urine volume causing congestion.

2. Hyperosmotic dehydration and electrolyte imbalance, such as hypokalemia or hypernatremia.

3. Growth and intellectual development disorders.

Treatment principles

1. The main purpose of symptomatic treatment is to replenish water, maintain water balance, and reduce the intake of solutes such as sugar and salt.

2. Hydrochlorothiazide can affect the distal renal tubule to produce a negative sodium balance, stimulate the proximal tubule to reabsorb sodium, and increase the absorption of water. Hydrochlorothiazide 25-50 mg 3 times a day can be given to reduce urine volume by about 50%.

3. Indomethacin reduces renal blood flow and counteracts the inhibitory effect of prostaglandins on cAMP. It is more effective when used in combination with hydrochlorothiazide. The usual dosage is 25 mg, 3 times a day.