Is lupus erythematosus hereditary? Why?

Lupus erythematosus is an autoimmune disease with a genetic tendency, but this does not mean there is a genetic effect. Everyone should be clear about this. Everyone must pay attention to the disease of lupus erythematosus and pay more attention to their physical condition in life.

1. Through the comparison and research of a large number of cases, we found that the incidence rate of lupus erythematosus in close relatives is 5-12%, and the incidence rate in fraternal twins is 23-69%, which shows that the occurrence of lupus erythematosus is related to genes. Experts point out that lupus nephropathy is at risk of worsening in the early stages of pregnancy, and worsening of the condition is more common during the postpartum period. Pregnancy is more dangerous if lupus erythematosus lesions are active before pregnancy or if lupus erythematosus is not treated regularly or adequately, resulting in rapid destruction of kidney function.

2. Generally speaking, people diagnosed with active lupus should avoid pregnancy within 2-3 years and cannot use contraceptives. After routine and adequate treatment, lupus nephropathy has no active clinical and renal pathological lesions for more than one year, and the maintenance dose of prednisone is 10-15 mg/day.

3. It was observed that miscarriage had occurred in the first three months of pregnancy, and lupus nephropathy often worsened in the last three months of pregnancy and thereafter. Long-term treatment with prednisone may result in low fetal birth weight. Therefore, the condition should be closely monitored during and after pregnancy. If clinical manifestations or laboratory abnormalities are found, the dose of prednisone should be increased as appropriate. During the labor period, hydrocortisone can be dripped, with the dosage being 1 times the amount of antenatal corticosteroids. Immediately after delivery, high-dose prednisone treatment should be started for 4-5 days, and then the dose should be gradually reduced according to the condition. Moreover, clinically we have seen that many children born to lupus patients are very healthy and do not suffer from lupus.

4. In fact, the cause of lupus erythematosus is the result of the combined effects of multiple factors including infection, endocrine and environmental influences. It should be pointed out in particular that clinical findings show that mental factors are a very important cause of inducing and aggravating the disease. Based on this, we can only say that lupus has a genetic tendency rather than being a hereditary disease, so lupus patients do not need to worry too much about passing their disease on to their children.