What are the causes of high bilirubin

If the bilirubin level in the human body is too high, timely treatment is required, otherwise it will cause some damage to the nervous system. There are many reasons why the body has high bilirubin, the most common of which is symptoms caused by liver disease.

Elevated total bile

Elevated total bilirubin is common in:

(1) Liver diseases: acute icteric hepatitis, acute yellow liver necrosis, chronic active hepatitis, cirrhosis, etc.

(2) Extrahepatic diseases: hemolytic jaundice, blood transfusion reaction due to blood type incompatibility, cholecystitis, cholelithiasis, etc.;

(3) Seen in toxic or viral hepatitis, hemolytic jaundice, pernicious anemia, and paroxysmal hemoglobinuria. Polycythemia, neonatal jaundice, internal bleeding, post-transfusion hemolytic jaundice, acute yellow liver atrophy.

Indirect increase

1. Hemolytic jaundice. Due to some hemolytic diseases, excessive destruction of red blood cells may result in increased indirect bilirubin in the blood;

2. Hepatocellular jaundice. When liver cells become diseased, bilirubin cannot be converted into bile normally. Due to the swelling of liver cells, the bile ducts in the liver are compressed, the excretion of bile is blocked, and the bilirubin level in the blood increases.

3. Blood transfusion error. Blood transfusion with incompatible blood types may cause hemolysis, destroy a large number of red blood cells, and cause a large amount of indirect bilirubin to be released into the blood.

4. Neonatal jaundice. It is mainly due to the increase of indirect bilirubin in the blood caused by blood type incompatibility between mother and child or congenital biliary tract malformation in the newborn.

Direct rise

1. Obstructive jaundice. It is mainly caused by bile duct obstruction (such as cholelithiasis, liver cancer, and pancreatic head cancer).

2. Some diseases that cause excessive destruction of liver cells, such as acute and chronic hepatitis, hepatocellular jaundice, cirrhosis, etc.