How to effectively treat negative blocking antibodies

If the blocking antibody is negative, the most common treatment is immunosuppressive immunoglobulin, plasma exchange, or oral cyclosporine a, which can effectively treat habitual abortion.

1. There are many traditional methods for treating immune abortion. For example, patients with positive anti-cardiolipin antibodies can use aspirin therapy and become pregnant after the antibodies turn negative. Dynamically monitor antiphospholipid antibodies after pregnancy. If the antibodies become positive, continue to use aspirin treatment. Other therapies such as immunosuppression, immunoglobulin and plasma exchange also have certain therapeutic effects. We have been committed to the research of immune infertility for many years and were the first to propose spousal leukocyte immunotherapy and oral cyclosporine A treatment, which have achieved more gratifying results.

2. The spouse's leukocyte immunotherapy method is to first separate and extract lymphocytes from the husband, and then inject them into the wife's body subcutaneously to build a safety barrier for the fetus in the mother's womb. If for various reasons immunotherapy between husband and wife is unsuccessful, lymphocytes from a third party (who has passed a health check) can be used instead. This will not change any genetic characteristics of the fetus. This treatment has been carried out for a long time, has a definite effect, and the successful pregnancy rate can reach over 90%. However, it takes a long time, brings great inconvenience to some non-local patients, and costs a lot. In addition, if the man has certain blood-borne infectious diseases (such as hepatitis B, HIV positive, etc.), this method is not suitable.

3. Oral cyclosporine a treatment: For patients who are not suitable for spouse's leukocyte immunotherapy, we use oral cyclosporine a for pregnancy preservation treatment. The plan is: continuous monitoring of basal body temperature. After the basal body temperature rose for one week, cyclosporine A was taken orally for 20 consecutive days. Cyclosporine A is a traditional immunosuppressant widely used in the treatment of organ transplantation and autoimmune diseases. Its application during pregnancy is mainly concentrated in pregnant women after organ transplantation. Its application in women with habitual miscarriage is a new development in the treatment of cyclosporine a. Our study confirmed that cyclosporine a can effectively promote trophoblast function and induce maternal-fetal immune tolerance. According to clinical statistics, the effectiveness of cyclosporine a in treating habitual abortion is over 85%.