What is the reason for low creatinine? Common causes are disease factors

Low creatinine indicates that there is a problem in some aspect of the body. This phenomenon is mostly caused by disease factors, so everyone must actively follow the doctor's advice for treatment, otherwise the consequences will be very serious.

1. What is creatinine?

Creatinine is a product of muscle metabolism in the body. Every 20g of muscle metabolism can produce 1mg of creatinine. Creatinine is primarily excreted by glomerular filtration. Creatinine in the blood comes from both exogenous and endogenous sources. Exogenous creatinine is the product of meat metabolism in the body; endogenous creatinine is the product of muscle tissue metabolism in the body. When the intake of meat food is stable and there is no major change in the body's muscle metabolism, the production of creatinine will be relatively constant.

2. The main reason for low creatinine

After the kidneys are invaded by various causes, the damaged kidney intrinsic cells first undergo phenotypic transformation, stimulating the kidney's fibroblasts to transform into myofibroblasts, and at the same time invade and stimulate the intrinsic normal renal tissue, causing the same lesions, thus forming an expanding and stimulating spread of the kidneys from point to surface, from local to overall, and thus entering the organic damage period (i.e., renal function damage period). At this time, due to the continuous damage to the kidneys, their function of excreting waste is reduced, resulting in the accumulation of toxins such as creatinine in the body, resulting in increased creatinine and urea nitrogen in the blood, decreased creatinine in the urine, and decreased filtration rate of both kidneys.

3. The creatinine value will also change for different groups of people

Generally speaking, pregnant women are most likely to have low blood creatinine. As for the reasons why pregnant women have low blood creatinine, experts believe that in most cases, it is due to malnutrition, most likely lack of protein, and excessive consumption of the body, which makes it difficult for all aspects of the body to withstand the original pressure, ultimately leading to anemia and malnutrition. Some pregnant women even cannot sustain the physical strength and do not get enough rest.

Therefore, in clinical practice or in real life, pregnant women are generally required to rest more and get enough sleep, and most pregnant women should strengthen their nutrition. This can also improve the nutritional environment of pregnant women, thereby improving the phenomenon of low blood creatinine.

In addition, most patients who have just recovered from a serious illness or have just suffered external trauma are also prone to low inosine levels. The reason for this phenomenon is that patients who have just recovered from a serious illness do not have enough physical strength to support and make up for the nutrition needed for a normal body. Long-term malnutrition leads to abnormal circulation and metabolism.