What is the normal value of fibrinogen

Fibrinogen is a protein. I believe many friends don’t know much about fibrinogen and don’t know the normal value of fibrinogen. So what is the normal value of fibrinogen? Next, this article will introduce you to the normal value of fibrinogen for your reference only. Friends who want to know what the normal value of fibrinogen is can take a look!

Fibrinogen A protein synthesized by the liver that helps in blood clotting. Fibrin is a monomeric protein produced during the coagulation process when thrombin cleaves fibrinopeptides A and B from fibrinogen. Simply put, it is a protein related to blood coagulation, namely, coagulation factor.

Fibrinogen is the most abundant coagulation factor in the blood and is also an acute response protein. Fibrinogen has dual biological activities. It is both a substrate for thrombin and a target for high-concentration plasmin. Therefore, fibrinogen plays an important role in both the coagulation system and the fibrinolytic system. Elevated plasma fibrinogen level is an independent risk factor for coronary thrombosis and is positively correlated with myocardial infarction and stroke. Elevated fibrinogen levels can be seen in certain acute or chronic infections, burns, shock, severe tissue damage and surgical operations. The fibrinogen level decreases in cases of severe liver damage or cirrhosis and disseminated intravascular coagulation (DIC).

What is the normal value of fibrinogen? The normal value of fibrinogen is: 2-4g/L. Because the equipment in different hospitals is different, there may be differences sometimes. Normal values ​​are usually marked on the examination form. It is recommended to observe and confirm.

This condition is seen in: hepatitis, multiple myeloma, malignant tumors, uremia, pregnancy, menstruation, postoperatively, DIC compensatory stage, rheumatic fever, sepsis, tuberculosis, burns, etc. when the level is elevated. Decrease is seen in: liver disease, DIC, hereditary afibrinogenemia, hereditary dysfibrinosis, etc.

How to measure fibrinogen? The existing methods can be roughly divided into three categories:

That is, (1) a method for forming fibrin based on the action of thrombin;

(2) Physicochemical determination method

(3) Immunological assay.

The first type of method is a functional assay, and the fibrin formed can be further divided into gravimetric method, phenol reagent colorimetric method and ultraviolet photometry, nitrogen measurement method, turbidity method and thrombin clotting time method.

The second method (physical and chemical determination method) is the most widely used in my country. This type of method can be divided into salting out method (including salting out with sodium sulfite, ammonium sulfate or sodium chloride, and determination by protein colorimetry or turbidimetry), thermal denaturation precipitation method and electrophoresis method.

The third method (immunological method) is to use pure fibrinogen as an antigen to immunize animals and produce polyclonal or monoclonal antibodies. Then the protein was determined by immunolatex, passive hemagglutination or reverse hemagglutination, one-way immunodiffusion, rocket electrophoresis and ELISA.

The above is an introduction to the normal value of fibrinogen. I believe that after reading the above introduction, you already know what the normal value of fibrinogen is. Generally speaking, the normal value of fibrinogen is 2-4g/L. If the fibrinogen value is higher or lower than this normal range, it may be caused by disease!