The role of lactate dehydrogenase

What is lactate dehydrogenase? What do you know about this disease? What kind of disease is this? What should we do? Should I go to a big hospital for a check-up immediately? What kind of people are susceptible to this disease? We are generally not familiar with these proper nouns, so what measures can we take to prevent them? Now, let’s take a look at the role of lactate dehydrogenase with me with your questions.

A concept

Lactate dehydrogenase is a glycolytic enzyme. Lactate dehydrogenase is present in the cytoplasm of all tissue cells in the body, with the highest content in the kidneys. Lactate dehydrogenase is an enzyme that catalyzes the conversion of pyruvate to lactate and is present in almost all tissues. There are six forms of isoenzymes, namely LDH-1 (H4), LDH-2 (H3M), LDH-3 (H2M2), LDH-4 (HM3), LDH-5 (M4) and LDH-C4, which can be separated by electrophoresis. The distribution of LDH isoenzymes has obvious tissue specificity, so it can be used to diagnose diseases based on its tissue specificity. In normal human serum, LDH2>LDH1. If myocardial enzymes are released into the blood, LDH1>LDH2. This indicator can be used to observe and diagnose myocardial diseases.

The reason for the increase

As for the reasons for high lactate dehydrogenase, there are the following aspects:

1. When the condition of a hepatitis B virus carrier worsens and becomes a hepatitis B patient, some liver cells are damaged and the levels of LDH4 and LDH5 in the serum will increase to varying degrees.

2. The treatment of hepatitis B, especially improper use of medication, and long-term use of the same medication can cause kidney toxicity. When nephrotoxicity occurs, the lactate dehydrogenase level in the serum will increase rapidly.

3. If hepatitis B is not treated appropriately and actively, it will develop to a certain extent and cause serious abnormalities in liver metabolism, leading to kidney failure, which will also cause an increase in lactate dehydrogenase levels.

4. Pulmonary infarction, pernicious anemia, shock and pleural effusion caused by tumor metastasis can cause elevated lactate dehydrogenase levels.

Three reasons for low

Lactate dehydrogenase is present in the cytoplasm of all tissue cells in the body, with the highest content in the kidneys. The normal range of serum lactate dehydrogenase is 100-300U/L. When lactate dehydrogenase is low, the common causes are as follows.

Reasons for low lactate dehydrogenase 1: Errors occurred during the inspection process;

Reason 2 for low lactate dehydrogenase: endocrine disorders;

Reasons for low lactate dehydrogenase level 3: overwork, poor sleep, bad mood, etc.

In short, low lactate dehydrogenase is generally not very serious and can be restored through conditioning. However, if lactate dehydrogenase is too high, it should be taken seriously. Pulmonary infarction, pernicious anemia, shock and pleural effusion caused by tumor metastasis can cause elevated levels of lactate dehydrogenase.

What to do

Elevated lactate dehydrogenase levels in serum are mainly caused by malignant tumors, hepatitis, cirrhosis and other diseases. Elevated lactate dehydrogenase levels are commonly seen in acute hepatitis, obstructive jaundice, myocarditis, malignant tumors, cirrhosis, liver cancer, muscular dystrophy, acute leukemia and pernicious anemia. Clinical medical practice shows that elevated serum lactate dehydrogenase in more than 80% of patients is caused by liver disease, especially acute hepatitis B, cirrhosis, liver cancer, etc. Therefore, if the patient finds that the lactate dehydrogenase level in the serum is no longer within the normal range, he or she should go to a liver disease hospital for testing in time and receive targeted treatment under the guidance of a doctor.

I believe that after reading the above content, everyone will have some understanding of lactate dehydrogenase. Everyone should take a good look at the above content to know what lactate dehydrogenase does. When you encounter it in the future, you will understand it a little bit and will not be so afraid. Lactate dehydrogenase is a very important indicator. This disease must attract everyone's attention. Otherwise, other troublesome symptoms will appear over time, and it will be too late to say anything then. Everyone must care about their own health and take good care of themselves and their families. After all, health is the first priority. The body cannot withstand the torture.