Increased alanine aminotransferase

When it comes to alanine aminotransferase, perhaps everyone will feel unfamiliar with it. This is indeed the case. Since most of us are not majoring in related fields and do not have many opportunities to come into contact with it in our daily lives, it is normal that we have not heard of it. Alanine aminotransferase is one of the many transaminases in the human body. Of course, it is also an indispensable transaminase in the human body because its role is very huge. Its normal work is a guarantee of normal liver function.

However, in today's society, people are facing increasing pressure in life and work, and have more and more opportunities to drink. As a result, many people cannot do without alcohol. Over time, the level of alanine aminotransferase in the body increases, causing serious damage to liver function. So what harm does elevated alanine aminotransferase have on the human body?

The normal reference value of alanine aminotransferase is 0-40U/L. Alanine aminotransferase is mainly present in the cytoplasm of liver cells, and its intracellular concentration is 1000-3000 times higher than that in serum. As long as 1% of liver cells are necrotic, serum enzymes can double. Therefore, alanine aminotransferase is recommended by the World Health Organization as the most sensitive detection indicator of liver function damage, and its normal value is 0-40U/L.

High alanine aminotransferase (GPT, ALT) is a very common phenomenon in clinical practice. The liver is the largest detoxification organ in the human body. Whether this organ is normal or not is very important to the human body. Elevated GPT is an important indicator of liver function problems. Among the common factors, various types of hepatitis can cause elevated GPT, which is caused by damage to the liver. Some drugs, such as anti-tumor drugs and anti-tuberculosis drugs, can cause liver damage. Drinking large amounts of alcohol and eating certain foods can also cause short-term damage to liver function.

High levels of alanine aminotransferase can cause insomnia, fatigue, poor appetite, low-grade fever, aversion to greasy food, jaundice, nausea, vomiting, abdominal pain, diarrhea, and discomfort in the liver area. Mild symptoms include sweating, drowsiness, thirst, and eye fatigue when reading. The main harm of high alanine aminotransferase is damage to the patient's liver, leading to continuous damage to liver cells. At the same time, the harm of high alanine aminotransferase is that it reduces the liver's metabolic and detoxification ability, resulting in drug metabolism and body toxins not being excreted in time, further increasing the burden on the liver. It can be said that this is a vicious cycle. If it is not stopped, the consequences of the disease development will be quite serious.

Therefore, in the future, when we feel fatigue, nausea, vomiting, insomnia, or memory loss at work or in life, it is best to go to the hospital for a check-up to see if it is due to some reason that the alanine aminotransferase in our body has increased, resulting in a pathological phenomenon. If so, you must receive treatment immediately, otherwise it will cause a certain degree of damage to your liver and your body and mind.