Drugs that reduce glutamyl transpeptidase

Generally speaking, if the body has high glutamyl transpeptidase, if there are no symptoms of discomfort, you can observe first, pay more attention to rest, and have regular checkups. However, if the body has pain or discomfort in the right upper abdomen, it is likely that you have hepatitis. It is best to go to the hospital to check liver function to see if the liver function is damaged, and then use drugs under the guidance of a doctor. What are the drugs that lower glutamyl transpeptidase?

What are the drugs that lower glutamyl transpeptidase?

If glutamyl transpeptidase is only slightly elevated, no special treatment is required. If the increase is obvious, it is not used to find the specific cause. Further hepatitis B two-pair-and-a-half examination, liver color ultrasound examination, etc. are needed. Oral compound glycyrrhizin tablets can be considered, but it must be taken under the guidance of a doctor.

Why is glutamyl transpeptidase high?

Glutamyl transpeptidase test is an enzymatic test that reflects the degree of liver damage. Glutamyl transpeptidase is a liver enzyme that mainly exists in the hepatic cytoplasm and intrahepatic bile duct epithelium. The normal range of glutamyl transpeptidase for adult females is 0-45U/L, and the normal range for adult males is 0-65U/L. If it is outside the range, it means that the glutamyl transpeptidase is high.

Elevated glutamyl transpeptidase levels may be caused by drinking, work pressure, staying up late, taking certain medications, etc. Patients with elevated glutamyl transpeptidase levels should pay close attention and go to a regular liver disease hospital for a check-up in a timely manner. High glutamyl transpeptidase levels can cause great harm to patients and aggravate their condition, especially those caused by obstructive jaundice, acute hepatitis, active chronic hepatitis, biliary tract infection, cirrhosis, etc., which can lead to hypersynthesis of liver enzymes in hepatocytes adjacent to the necrotic area. If the level is elevated for a long time, there may be a tendency to liver necrosis.

The general medical decisive level is: glutamyl transpeptidase <25U/L, which can exclude both pathological and biological variations; glutamyl transpeptidase is 50-200U/L higher, and biological variations including pharmacological causes should be checked; glutamyl transpeptidase is higher than 200U/L, which is usually caused by hepatobiliary disease. Specifically, the reasons for high glutamyl transpeptidase include the following aspects:

1. In chronic active hepatitis, glutamyl transpeptidase is often 1 to 2 times higher than normal. If it remains elevated for a long time, there may be a tendency for liver necrosis.

2. In acute viral hepatitis, the hepatocytes adjacent to the necrotic area have hypersynthesis of enzymes, causing an increase in serum glutamyl transpeptidase.

3. Changes in serum glutamyl transpeptidase during cirrhosis depend on whether the intrahepatic lesions are active and their causes.

4. Glutamyl transpeptidase levels are almost always elevated in patients with alcoholic hepatitis and alcoholic cirrhosis, which is an important feature of alcoholic liver disease.

5. Glutamyl transpeptidase is often elevated in patients with fatty liver, but in general, serum glutamyl transpeptidase activity in nutritional fatty liver does not exceed twice the normal value.

6. In patients with primary or metastatic liver cancer, the enzyme is mostly moderately or highly increased, which can be several times or even dozens of times greater than normal, while tumors of other systems are mostly normal.

7. When the intrahepatic or extrahepatic bile duct is obstructed, the excretion of glutamyl transpeptidase is blocked and refluxes into the blood with bile, causing an increase in serum glutamyl transpeptidase.

Excessive drinking leads to elevated glutamyl transpeptidase

In addition, heavy drinking, excessive consumption of high-protein supplements, and taking certain liver-damaging medications can all lead to varying degrees of elevated glutamyl transpeptidase. Excessive work or life pressure puts the human body in an overloaded state and can also cause patients of different age groups to have varying degrees of elevated glutamyl transpeptidase.

It can be seen that elevated glutamyl transpeptidase is related to many factors. Clinically, it is difficult to determine the cause of the disease based on only one elevated glutamyl transpeptidase level. Therefore, when the glutamyl transpeptidase level is high, you should first go to the hospital for further examination and then take symptomatic medication after the cause is determined. Special reminder: if people who do not drink alcohol have elevated serum GGT levels, they should have a recheck after one or two weeks. If their serum GGT is still higher than normal during the recheck, the cause should be found in time so that symptomatic treatment can be given.