What are the symptoms of advanced lung cancer bone metastasis? These are the common symptoms of advanced lung cancer bone metastasis

Oncologists say that many cancer patients will have varying degrees of metastasis in the late stages of the disease. Due to different conditions, the sites of metastasis are also different. Take lung cancer as an example. Generally, patients with advanced lung cancer are more likely to have bone metastasis. Therefore, for patients with advanced lung cancer, it is important to know more about the symptoms of lung cancer bone metastasis, which will be helpful for early detection and treatment. Please allow oncologists to introduce the specific content in detail below.

【Late-stage symptoms of lung cancer bone metastasis】

Bones are a common site for lung cancer metastasis, and the incidence of lung cancer bone metastasis is related to the site and pathological type of the primary cancer. Adenocarcinoma has the highest incidence of bone metastasis, followed by small cell lung cancer and squamous cell carcinoma. The lesions of bone metastasis are mainly multiple. The common sites are: ribs, thoracic vertebrae, lumbar vertebrae, and pelvis; adenocarcinoma mainly metastasizes to the chest and pelvis. Lung cancer bone metastasis is mainly adenocarcinoma, and it often invades the ribs and thoracic vertebrae. The reason may be that adenocarcinoma often occurs around the lungs, which can easily cause direct invasion and involve the ribs and thoracic vertebrae. In addition, tumor cells reach the bones through the blood circulation, and are also prone to grow and reproduce in the trunk bones containing red bone marrow, but rarely grow in the long bones of the limbs containing yellow bone marrow.

Symptoms of lung cancer caused by bone metastasis include bone pain and pathological fractures. Bone metastasis is caused by hematogenous spread, and the most common sites are the pelvis, ribs, vertebrae and proximal long bones. Pain is the most common symptom of lung cancer. Periosteal inflammation and thickening are the root causes of pain, and bone metastasis usually occurs before bone pain occurs. 18.3% of patients with early non-small cell lung cancer develop bone metastasis, but only 27.2% develop bone pain, and most patients have no pain symptoms.

Bone metastasis is also one of the main causes of death from lung cancer. The diagnosis rate of lung cancer bone metastasis is relatively low, and bone pain, pathological fractures, local compression and hypercalcemia also complicate treatment. Among patients with small cell lung cancer, 40% have positive bone scintigraphy at diagnosis, and bone metastasis is often diagnosed when there are no symptoms. Primary lung cancer bone metastasis is usually osteolytic. Pathological fractures occur when bone strength is destroyed, and collapse and expansion of the vertebral body can cause spinal cord compression. Paraneoplastic syndrome without bone destruction and osteolytic bone metastasis may both cause hypercalcemia and lead to worsening of the disease.

Late symptoms of lung cancer bone metastasis: There are generally no symptoms in the early stages of bone metastasis, and bone isotope scanning can reveal diseased bones. Symptoms of bone metastasis are related to the location and number of tumor metastases. For example, chest pain caused by rib metastasis of lung cancer is often manifested as pain localized in the chest wall with clear tenderness points. Spinal cord metastasis causes pain in the middle of the back or the lesion site, while bone metastasis of the limbs or trunk causes localized pain in that area. Bone metastasis is not a direct cause of life threats to lung cancer patients, but if the tumor metastasizes to the body's weight-bearing bones such as the cervical, thoracic, and lumbar vertebrae, it can cause serious consequences such as paralysis. Therefore, patients with bone metastasis of lung cancer should be treated promptly.

The above is a detailed introduction to the late-stage symptoms of lung cancer bone metastasis. Oncologists say that early detection and treatment can reduce the occurrence of bone metastasis. If you want to know what symptoms will appear in the early stage of lung cancer, you can consult an expert online, and the expert will answer your questions one by one.