What are the causes of primary liver cancer? Six reasons can lead to primary liver cancer

What are the causes of primary liver cancer? This question is very important to us. In life, primary liver cancer, as a type of liver cancer, is extremely harmful to our bodies and also causes serious damage to our happy lives. Therefore, in order to better ensure our health, it is very important to pay attention to the causes of primary liver cancer and do a good job in preventing liver cancer.

(1) Chemical carcinogens

Chemical substances that can cause liver cancer are mainly n-nitroso compounds, such as nitrosamines and nitrosamides, etc. In addition, pesticides, alcohol, safrole, etc. can also induce liver cancer and are one of the causes of primary liver cancer.

(2) Water source pollution

Severe pollution of drinking water is one of the causes of primary liver cancer, especially polluted ditch water, followed by river water, and well water is the lowest. Therefore, in villages without tap water facilities, drinking well water should be encouraged.

(3) Aflatoxin

Aflatoxin is one of the causes of primary liver cancer. In high-incidence areas of liver cancer, especially in the south where corn is the staple food, surveys suggest that the prevalence of liver cancer may be related to the contamination of grain by aflatoxin. The level of aflatoxin M1, a metabolite of aflatoxin B1, in human urine is very high. Aflatoxin B1 is the strongest carcinogen for animal liver cancer, but there is no direct evidence of its relationship with human liver cancer.

(4) Immune status

Some people believe that the plasma of liver cancer patients contains a blocking factor that can inhibit cellular immunity and protect liver cancer cells from being killed by immune cells. As the cause of primary liver cancer, it has been proven that alpha-fetoprotein (AFP) can inhibit the phagocytosis of lymphocytes and macrophages.

(5) Gene mutation

In recent years, some people believe that mutagen and virus in the environment stimulate the activation of liver cell division response pathways, causing cell point mutation and gene translocation, which is a possible factor in accelerating the proliferation of cancer cells. In the etiology of primary liver cancer, this point should also be paid attention to.

(6) Other factors

What are the causes of primary liver cancer? Overnutrition (macronutrients) or nutritional deficiency (such as vitamin A and B1 deficiency), hemochromatosis, parasitic infection and heredity are also causes of primary liver cancer.