The fruit raspberry can significantly inhibit the proliferation of liver cancer cells, weaken the expression of vascular endothelial growth factor in liver cancer cells, and enhance the expression of wild p53 tumor suppressor gene. This National Natural Science Foundation project completed by Dr. Liu Ming of the Fourth Affiliated Hospital of Harbin Medical University has successfully locked two specific protein targets of raspberry to prevent liver cancer growth for the first time at home and abroad, providing an important theoretical basis for the prevention of primary liver cancer by fruits and vegetables. Raspberry, also known as raspberry, tray, and raspberry, is a perennial deciduous shrub of the genus Rubus in the Rosaceae family. There are more than 750 species. Because its fruit shape, color, and taste are similar to strawberries but grow on trees, it is named raspberry. This fruit contains a large amount of anti-aging substances such as vitamin C, E, superoxide dismutase, γ-aminobutyric acid, and anti-cancer substances such as tannic acid. Among them, the content of vitamin E and tannic acid is the highest among all fruits. In the United States, red raspberries are regarded as cancer killers and people praise them as "rubies". It is well known that oxidative damage to genetic material is one of the causes of the vast majority of tumors. The results of the study showed that as the concentration of phytochemicals in raspberries increased, the ability to resist oxidative damage also increased. The inhibition rate of raspberry extracts at different concentrations on the liver cancer cell line HepG-2 showed a gradual increase, with the highest inhibition rate reaching about 90%. In a stable rat primary liver cancer model established using chemical poisons aflatoxin and diethylnitrosamine, as the concentration of raspberry extract increased, the tumor diameter on the liver of the experimental group rats became smaller, the number of tumors decreased, the tumor formation rate decreased, and the degree of nodules was reduced. At the same time, proteomic studies have shown that there are two protein spots that are very likely to be protein targets for raspberries to prevent liver cancer. Experts have pointed out that currently, there are two synergistic risk factors that greatly increase the chance of liver cancer. One is chronic infection with the hepatitis B virus, and the other is chronic exposure to aflatoxin, a highly toxic liver toxin produced by mold that contaminates staple foods. One of the important ways to reduce the impact of these two carcinogenic factors is chemical prevention, that is, taking drugs or food supplements to offset the harm of aflatoxin. In the future, using phytochemicals extracted from raspberries, reasonably matching and forming preventive agents, will be very helpful in preventing the occurrence of liver cancer, inhibiting the development of liver cancer, and improving the survival rate of patients with this disease. How to consume fruits such as raspberries in a reasonable way? First, eat at least two kinds of fruits such as raspberries, grapes, apples or oranges every day. If you eat them with three or more vegetables such as cauliflower, tomatoes, carrots, the effect will be better. Second, after soaking and washing fruits such as raspberries, grapes, and apples, it is best to eat them whole without peeling them. Third, people at high risk of liver cancer should consume no less than 200 grams of raspberries every day, and eat them between meals. The effect will be better if eaten with two other fruits and two vegetables. |
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