Is bladder cancer hereditary? What are the causes of bladder cancer?

Bladder cancer is not a genetic disease, but it is related to genetic factors and may be caused by gene mutations such as oncogene activation and oncogene inactivation.

1. Oncogene activation

Bladder cancer has the characteristic of familial clustering, so if someone in the family has bladder cancer, the chances of other direct relatives suffering from bladder cancer will be higher. Genes contain cancer cell activity or hidden factors. When stimulated by the body or other external factors, these oncogene factors will be activated. Not only will it increase the chance of suffering from bladder cancer, but it will also affect the invasiveness and prognosis of bladder cancer.

2. Inactivation of tumor suppressor genes

The occurrence of bladder cancer is related to hereditary factors, but it is not absolute. It is just that if a relative has bladder cancer, the chances of other people suffering from bladder cancer will be higher. This is mainly because other family members have tumor suppressor genes, which inhibit the activity of oncogenes. When the tumor suppressor genes lose their activity, oncogenes cannot be suppressed, and bladder cancer will occur.