What are the predisposing factors of osteosarcoma

What are the inducing factors of osteosarcoma? Osteosarcoma refers to a malignant connective tissue tumor in which tumor cells can directly produce tumor bone and bone-like tissue. Its incidence rate ranks first among primary malignant tumors, and the harm it brings to patients is immeasurable. So, what are the inducing factors of osteosarcoma? Let's take a look.

Osteosarcoma is the most common type of malignant bone tumor. It develops from the mesenchymal cell line. The rapid growth of the tumor is due to the direct or indirect formation of tumor bone-like tissue and bone tissue through the cartilage stage. Under the influence of external factors (such as viruses), the weight-bearing bones of the lower limbs cause cell mutations, which may be related to the formation of osteosarcoma.

Typical osteosarcomas originate from the bone. Another completely different type of osteosarcoma is the osteosarcoma that is parallel to the bone cortex and originates from the periosteum and nearby connective tissue. The latter is less common and has a slightly better prognosis. Osteosarcoma is related to genetics, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and fibrous dysplasia of bone. In addition, some cases are caused by the malignant transformation of other benign tumors.

Modern medicine has not yet fully understood the cause of this disease. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions that occur in long bones are mostly located in the epiphysis, and a few are in the middle of the shaft. The tumor develops rapidly along the medullary cavity, spreading to the epiphysis on the one hand. On the other hand, the tumor occasionally spreads to the shaft. In addition, the tumor also develops rapidly outward, invading the Hastelloy system in the bone cortex, causing vascular nutrition disorders, and the bone cortex is then destroyed. The tumor quickly reaches the periosteum and invades the adjacent muscle tissue outward.

Radical surgery should be performed to treat osteosarcoma. If conditions permit, local extensive resection can be performed to preserve the limb. In addition, a biopsy should be performed before amputation. The closer the tumor is to the trunk, the higher the mortality rate. Immunotherapy is intravenous infusion of lymphocytes or interferon and transfer factor, but the efficacy is not yet certain.