How is osteosarcoma formed

How is osteosarcoma formed? The incidence of osteosarcoma ranks first among primary malignant tumors. The tumor is highly malignant and has a very poor prognosis. It can metastasize to the lungs within a few months. The survival rate after amputation is only 5% to 20% within 3 to 5 years. Therefore, we must understand the cause of the disease, do a good job of prevention, and reduce the incidence of the disease. So, how is osteosarcoma formed?

1. Osteosarcoma originates from primitive progenitor cells, which have multipotential characteristics and can differentiate into bone, cartilage and fiber. Therefore, in addition to malignant osteoblasts, osteosarcoma also has chondroblasts and fibroblasts. According to the amount of these three cell components, central osteosarcoma can be divided into osteoblasts (osteoblasts), chondroblasts (cartilage) and fibroblasts (fibroblasts).

2. Modern medicine has not yet fully understood the cause of this disease. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions occurring in long bones are mostly located in the epiphysis, and a few in the middle of the shaft. The tumor develops rapidly along the medullary cavity, spreading to the epiphysis on the one hand. On the other hand, the tumor occasionally spreads to the shaft.

3. The tumor can develop rapidly outwards, invading the Hastings system in the bone cortex, causing vascular nutrition disorders, and then destroying the bone cortex. The tumor quickly reaches the periosteum and invades the adjacent muscle tissue. In addition, it is related to genetics, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and fibrous dysplasia of bone. In some cases, other benign tumors are malignant.

Osteosarcoma is the most common type of malignant bone tumor. It develops from the mesenchymal cell line. The rapid growth of the tumor is due to the direct or indirect formation of tumor bone-like tissue and bone tissue during the cartilage stage. Under the influence of external factors (such as viruses), the weight-bearing bones of the lower limbs cause cell mutations, which may be related to the formation of osteosarcoma. If you have osteosarcoma, you must go to the hospital for diagnosis and treatment in time to facilitate recovery.