What are the causes of osteosarcoma

What are the causes of osteosarcoma? There are certain reasons for the occurrence of diseases. We need to know more about the inducing factors of the disease in order to resist its occurrence at the root. Osteosarcoma is a common malignant tumor that brings considerable harm to patients. So, what are the causes of osteosarcoma?

Osteosarcoma refers to a primary malignant bone or soft tissue tumor produced by osteoblastic mesenchymal cells, composed of neoplastic osteoblasts and osteoid tissue. It is the most common malignant bone tumor, accounting for about 34% of malignant bone tumors. The tumor is highly malignant and has a very poor prognosis. It may metastasize to the lungs within a few months, and the survival rate 3 to 5 years after amputation is only 5% to 20%.

Modern medicine has not yet fully understood the cause of this disease. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions that occur in long bones are mostly located in the epiphysis, and a few are in the middle of the shaft. The tumor develops rapidly along the medullary cavity, spreading to the epiphysis on the one hand. On the other hand, the tumor occasionally spreads to the shaft. In addition, the tumor also develops rapidly outward, invading the Hastelloy system in the bone cortex, causing vascular nutrition disorders, and the bone cortex is then destroyed. The tumor quickly reaches the periosteum and invades the adjacent muscle tissue outward.

Osteosarcoma is the most common type of malignant bone tumor. It develops from the mesenchymal cell line. The rapid growth of the tumor is due to the direct or indirect formation of tumor bone-like tissue and bone tissue during the cartilage stage. Under the influence of external factors (such as viruses), the weight-bearing bones of the lower limbs cause cell mutations, which may be related to the formation of osteosarcoma. If you have osteosarcoma, you must go to the hospital for diagnosis and treatment in time to facilitate recovery.

In addition, it is related to heredity, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and bone fibrous dysplasia. Some cases are caused by the malignant transformation of other benign tumors. The pathogenesis of osteosarcoma is still not very clear. Its histological feature is that the proliferating spindle-shaped tumor cells directly produce osteoid matrix or immature bone. However, its hair type is different and its histological features are also different.