How much do you know about osteosarcoma

How much do you know about osteosarcoma? Osteosarcoma is a highly malignant tumor disease, which is more common in adolescents or children under 20 years old. It is the most common bone malignant tumor in children. The main symptoms are pain and lumps. In severe cases, lameness will occur, which has a great impact on patients. So, how much do you know about osteosarcoma?

Modern medicine has not yet fully understood the cause of osteosarcoma. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions that occur in long bones are mostly located in the epiphysis, and a few are in the middle of the shaft. The tumor develops rapidly along the medullary cavity, spreading to the epiphysis on the one hand. On the other hand, the tumor occasionally spreads to the shaft.

In addition, the tumor also develops rapidly outward, invading the Hastings system in the bone cortex, causing vascular nutrition disorders, and the bone cortex is then destroyed. The tumor quickly reaches the periosteum and invades the adjacent muscle tissue. In addition, it is related to genetics, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and fibrous dysplasia of bone. In some cases, other benign tumors are malignant.

The pathogenesis of osteosarcoma is still unclear. Its histological feature is that the proliferating spindle-shaped tumor cells directly produce osteoid matrix or immature bone. However, its histological features are different due to different hair types. Osteosarcoma originates from primitive progenitor cells, which have multipotential characteristics and can differentiate into bone, cartilage and fiber. Therefore, in addition to malignant osteoblasts, osteosarcoma also has differentiation of chondroblasts and fibroblasts.

Osteosarcoma is still a malignant tumor with a high mortality rate in children and adolescents, but early detection and timely treatment have greatly improved the survival rate of the disease. After the pathological diagnosis of osteosarcoma, early chemotherapy or radiotherapy begins, and the removal of tumor tissue is an important step in the treatment of osteosarcoma.