What causes pituitary tumors

What causes pituitary tumors? The occurrence of diseases is caused by certain factors. Pituitary tumors are a chronic disease that develops slowly. They are generally benign tumors, but patients should not take it lightly. Once discovered, they should be actively treated. Many people do not know what causes the disease. Let's take a look at what causes pituitary tumors.

Pituitary tumors are a group of tumors that develop from the anterior and posterior pituitary and residual cells of the craniopharyngeal epithelium. About 10% of intracranial tumors have obvious clinical symptoms. Males are slightly more likely to have pituitary tumors than females. Pituitary tumors usually occur in young and middle-aged people, often affecting the patient's growth and development, reproductive function, learning and work ability.

1. Hypothalamic regulatory dysfunction (35%):

Hypothalamic polypeptide hormones promote the proliferation of pituitary cells. For example, after the GHRH gene is transplanted, it can cause the proliferation of rat GH cells and then develop into a true pituitary tumor. The lack of inhibitory factors can also promote tumorigenesis. For example, ACTH adenoma can occur in patients with primary adrenal cortex insufficiency.

2. Pituitary cell defects (25%):

Pituitary adenomas arise from a single mutated cell, followed by monoclonal expansion or cell replication due to its own mutation. The intervention of external precipitating factors or the lack of inhibitory factors:

①Defects in DA (dopamine) receptor gene expression.

②The role of oncogenes and tumor suppressor genes: Oncogenes are actually a type of genes involved in the regulation of normal cell growth. Some oncogene products are growth factors and their receptors, while others are involved in the transmission of growth signals within cells. Abnormalities in their expression can lead to abnormal cell proliferation.

Pituitary tumor is a common tumor disease that occurs in the brain. There are many types of it in clinical practice, and each type presents different symptoms. In addition, the cause of each patient's illness is also different. During treatment, it is necessary to make a comprehensive judgment based on the cause, symptoms and other aspects, so as to adopt the treatment plan that best suits the patient, in order to ensure the best treatment effect.