Why do you get bile duct cancer

Why do people get bile duct cancer? Biliary duct cancer is very harmful to the body. Once the disease occurs, it is difficult to cure, so we should prevent it in our lives, pay attention to dietary hygiene, develop good work and rest habits, and eliminate pathogenic factors. Today I will introduce to you the causes of bile duct cancer. Let’s take a look.

Causes of bile duct cancer:

1. Chronic inflammation and infection factors of the bile duct Long-term chronic inflammatory stimulation is the basis for the occurrence of bile duct cancer, because clinically found that diseases related to bile duct cancer can lead to chronic inflammation of the bile duct.

2. Bile duct and gallbladder stones 20% to 57% of bile duct cancer patients have gallstones, so it is believed that chronic stimulation from stones may be a carcinogenic factor.

3. Ulcerative colitis. It has been reported that the incidence of bile duct cancer in patients with ulcerative colitis is 10 times higher than that in the general population.

4. Biliary duct cystic malformation (congenital biliary dilatation) It has become a consensus that congenital bile duct cysts are prone to cancer. The incidence of bile duct cancer in patients with congenital bile duct cysts is as high as 2.5% to 28%. Patients with bile duct cystic malformations develop cancer 20 to 30 years earlier than normal people.

5. Liver fluke (Clorchis sinensis) infection Infection with Clonorchis sinensis is also believed to be related to the occurrence of cholangiocarcinoma. Although Clonorchis sinensis mostly parasitizes in the intrahepatic bile duct, it can also parasitize in the extrahepatic bile duct. The worm itself and its metabolic products cause long-term stimulation to the bile duct mucosal epithelium, causing hyperplasia of the bile duct mucosa, tumor-like changes, and cancer.

6. History of biliary surgery Cholangiocarcinoma may occur many years after surgery and may occur in bile ducts that do not contain stones. It is mainly caused by chronic biliary infection leading to epithelial anaplasia, often after internal biliary drainage.

7. Among patients with a history of contact with radioactive thorium dioxide and thorium, the onset age of cholangiocarcinoma is 10 years earlier than that of those with no history of thorium exposure. The average incubation period is 35 years (after exposure to thorium), and it mostly occurs at the distal end of the intrahepatic bile duct tree.

8. Malignant transformation of sclerosing cholangitis: Patients with primary sclerosing cholangitis (PSC) have a higher chance of developing bile duct cancer than the general population. PSC is also related to ulcerative colitis.

9. Hepatitis B virus infects the domestic part. The mass forms a nodule protruding far into the bile duct, the base of the nodule is continuous with the bile duct wall, and the inner surface of the bile duct is often irregular. The tumor is generally small, with a wide base and an irregular surface. This type of tumor often infiltrates along the bile duct mucosa, and the degree of infiltration into the surrounding tissues and blood vessels of the bile duct is less than that of the sclerotic type. The surgical resection rate is high and the prognosis is good.

The above content is an introduction to the causes of bile duct cancer. I hope it can be helpful to everyone. I hope that by introducing the above factors that induce bile duct cancer, it can sound the alarm for everyone to actively avoid these factors in daily life and reduce the incidence of bile duct cancer. I hope that patients with bile duct cancer can recover soon and get rid of the troubles of bile duct cancer as soon as possible.