What causes osteosarcoma

We all know that once osteosarcoma is contracted, it is difficult to cure. So what causes osteosarcoma? Here I will first introduce to you what osteosarcoma is. Osteosarcoma, also known as osteogenic sarcoma, is a common malignant bone tumor that occurs in adolescents or children under the age of 20. It is the most common malignant bone tumor in children, accounting for about 5% of pediatric tumors. After understanding what osteosarcoma is, let's learn about what causes osteosarcoma?

There are several causes of osteosarcoma:

1. Viruses: Experiments have shown that animal osteosarcoma is related to viral infection, but there is no definite data to explain the relationship between human osteosarcoma and viruses.

2. Malignant transformation of benign bone diseases: such as multiple osteochondromas, Paget's disease of bone, fibrous dysplasia of bone, etc., which may lead to osteosarcoma, also known as secondary osteosarcoma.

3. Active growth of bones.

4. Radiation: Experiments have shown that any radioactive substance that can accumulate in the bones can induce osteosarcoma; local radiation therapy for certain bone diseases such as giant cell tumor of bone, aneurysmal bone cyst or extra-bone tumors such as breast tumor, retinoblastoma, etc. can occasionally cause secondary osteosarcoma.

5. What are the causes of osteosarcoma? Heredity: The retinoblastoma gene Rb gene is located on chromosome 13q14. It is currently known that it is a tumor suppressor gene mutation or deletion. Patients with hereditary retinoblastoma have a much higher risk of osteosarcoma than the average person. In recent years, it has been found that some osteosarcoma patients also have mutations in the Rb gene.

The above are several factors that cause osteosarcoma. As long as we pay more attention to these issues in our daily lives, osteosarcoma will stay away from us.