What should be considered when osteosarcoma recurs in children

The harm of osteosarcoma is frightening. In the treatment process, drug insensitivity may occur, which makes treatment difficult. The current medical level cannot achieve satisfactory therapeutic effects. Poor prognosis is still a difficulty. Incomplete removal of lesions is prone to recurrence. Now let's talk about what issues should be considered when pediatric osteosarcoma recurs:

Osteosarcoma is the same as other tumors. Its pathogenic factors are very complex. Generally speaking, the internal factors exist first, and the external factors occur through the internal factors. The internal factors include the quality theory, the genetic theory, the endocrine theory, etc.; the external factors include the chemical elements and the slow stimulation theory of internal and external radiation, the virus infection theory, etc. Multiple osteochondromas and fibroid hyperplasia are both related to the family. Bone tumors often occur between the ages of 10 and 30, indicating that the vigorous development and growth of bones is related to the occurrence of tumors. Therefore, it can be considered that during the growth and maturation of bones, the body is more sensitive to the stimulation of the above factors, so that it is easy to become a tumor or tumor-like lesions. Benign bone tumors can become malignant: for example, chondroma, osteochondroma, osteoblastoma, etc. can all become malignant sarcomas, and fibroid dysplasia in tumor-like lesions can also become malignant sarcomas. Some patients with bone tumors often recall a history of trauma to the affected part, such as sprains, bruises, etc. In fact, this type of trauma will not cause bone changes, and osteosarcoma occurring at the fracture site is extremely rare. It is likely that when the tumor develops to a certain extent, the trauma causes obvious symptoms and attracts attention.

Since the first record of bone tumor in Huangdi Neijing, doctors of successive dynasties have further explored and supplemented the understanding and treatment of bone tumor from different aspects, which has gradually deepened the understanding of bone tumor. According to the theories of various doctors, the occurrence of bone tumor is always caused by insufficient kidney qi, imbalance of yin and yang, and dysfunction of viscera, which leads to cold, dampness and toxic evil taking advantage of the opportunity to enter the bones, and blood stasis and accumulation in the bones. For example, the invasion of external evil from the surface to the inside, deep into the bones, and accumulation for a long time; the injury caused by falling and hitting, the blood vessels are damaged, and the blood stasis accumulates and does not disperse into tumors; insufficient endowment, or excessive labor, excessive sexual intercourse, depletion of kidney qi, kidney is responsible for bone and marrow production, and kidney qi depletion leads to bone lesions; excessive eating, damage to spleen and stomach, spleen failure, dampness and phlegm, accumulation into tumors; mental stimulation, emotional depression, excessive five emotions, resulting in imbalance of yin and yang, disharmony of qi and blood, and blockage of meridians, leading to bone tumors.

Factors leading to recurrence of osteosarcoma after surgery:

1. Age. The recurrence of osteosarcoma after surgery is also closely related to age, because the level of cell metabolism is closely related to age. According to surveys, the elderly have fewer recurrences after surgery, while young people have more. The recurrence after surgery is a factor in the relatively low degree of malignancy and better prognosis.

2. Immunity. Whether osteosarcoma will recur after surgery is also closely related to the patient's immunity. Therefore, the patient's immunity has already dropped significantly before surgery. If you do not pay attention to strengthening nutrition after surgery, it will create conditions for the metastasis of cancer cells.

3. There is no regular follow-up visit. Some patients do not get relief from their symptoms after surgery and think they are cured, thus relaxing the subsequent consolidation treatment. They do not have regular check-ups and take medications on time, which greatly increases the chance of recurrence.

Warm reminder: Osteosarcoma patients should not take it lightly after surgery. Postoperative treatment and care are also very important. Experts recommend that patients choose biological therapy for adjuvant treatment after surgery, which can clear residual cancer cells after surgery, prevent recurrence and metastasis of the disease, and improve the patient's quality of life.