Is osteosarcoma hereditary?

The pain caused by the appearance of osteosarcoma is immeasurable. It not only reduces the patient's physical health, but also endangers life safety in severe cases. Many patients are worried about whether osteosarcoma is hereditary. Before treatment, patients must first understand the cause of the sarcoma to understand whether it will be inherited. Next, I will explain to patients from the cause of osteosarcoma whether osteosarcoma is hereditary.

Osteosarcoma refers to a malignant connective tissue tumor in which tumor cells can directly produce tumor bone and bone-like tissue. Its incidence ranks first among primary malignant tumors. Osteosarcoma pain is an early symptom and can occur before the tumor appears. It is intermittent pain at first and gradually turns into continuous severe pain, especially at night. Pain occurs earlier and more severely in large malignant tumors. There is often a history of local trauma. The tumor near the bone end near the joint is large, with varying hardness and tenderness. The local temperature is high, the veins are dilated, and sometimes pulsation can be felt. There may be pathological fractures, and the overall health gradually declines to exhaustion. Most patients have lung metastasis within a year.

Modern medicine has not yet fully understood the cause of osteosarcoma. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions occurring in long bones are mostly located in the epiphysis, and a few are in the middle of the shaft. The tumor develops rapidly along the medullary cavity, spreading to the epiphysis on the one hand. On the other hand, the tumor occasionally spreads to the shaft. In addition, the tumor also develops rapidly outward, invading the Hastelloy system in the bone cortex and causing vascular nutrition disorders. The bone cortex is then destroyed, and the tumor quickly reaches the periosteum and invades the adjacent muscle tissue outward. In addition, it is related to heredity, exposure to radioactive substances, viral infection, etc. It can also be secondary to deformed osteitis and bone fibrous dysplasia. Some other cases are caused by the malignant transformation of other benign tumors.

The pathogenesis of osteosarcoma is still unclear. Its histological feature is that the proliferating spindle-shaped tumor cells directly produce osteoid matrix or immature bone. However, its histological features are different due to different hair types. Osteosarcoma originates from primitive progenitor cells, which have multipotential characteristics and can differentiate into bone, cartilage and fiber. Therefore, in addition to malignant osteoblasts, osteosarcoma also has differentiation of chondroblasts and fibroblasts.

Osteosarcoma is related to heredity, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and fibrous dysplasia of bone. Some cases are caused by the malignant transformation of other benign tumors. Although osteosarcoma is a malignant tumor and an autologous cell lesion, it is not hereditary. Patients can rest assured, but if they find symptoms of osteosarcoma, they must actively seek medical treatment.