Treatment methods for endometrial cancer

What are the treatments for endometrial cancer? Endometrial cancer is a common malignant tumor that occurs in the female reproductive tract. This disease is very harmful to patients. It usually occurs in women aged 58-61. In order to get rid of the troubles of this disease as soon as possible, patients should go to a regular hospital for examination and treatment in time to avoid affecting their condition. With the continuous advancement of medical technology, there are more and more methods to treat endometrial cancer, and patients have more and more room for choice. Let us give a detailed introduction below, hoping to help everyone.

1. Surgical treatment

Surgery is the preferred treatment for endometrial cancer, especially for early cases. Patients with stage I endometrial cancer should undergo subradical hysterectomy and bilateral salpingo-oophorectomy. Those with any of the following conditions should undergo pelvic and para-aortic lymph node sampling and/or dissection: Pathological type is clear cell carcinoma, serous carcinoma, squamous cell carcinoma, or G3 endometrioid carcinoma. Invasion of the muscle layer depth ≥ 1/2. Tumor diameter > 2cm. Stage II should undergo extensive hysterectomy and bilateral pelvic and para-aortic lymph node dissection. Ascites should be taken immediately after entering the abdominal cavity. If there is no ascites, 200ml of normal saline should be injected to flush the abdominal cavity. Ascites or peritoneal washings should be centrifuged and precipitated to find cancer cells.

2. Progestin therapy

Progestin therapy can be considered for patients with advanced endometrial cancer or recurrent endometrial cancer, those who cannot undergo surgical resection or those who are young, early-stage, and require the preservation of fertility. Various synthetic progestin preparations such as medroxyprogesterone and progesterone caproate can be used. The dosage should be large, medroxyprogesterone 200-400mg/d; progesterone caproate 500mg, twice a week, at least 10-12 weeks to evaluate whether there is any effect. Its mechanism of action may be to act directly on cancer cells, delay the replication of DNA and RNA, and thus inhibit the growth of cancer cells. Progesterone therapy is more effective for endometrial cancer with good differentiation, slow growth, and high estrogen and progesterone receptor content. The side effects are mild, which can cause water and sodium retention, edema, drug-induced hepatitis, etc., and gradually improve after stopping the drug.

3. Radiation therapy

Although adenocarcinoma is not sensitive to radiation, radiotherapy can be considered for the elderly or those with severe complications who cannot tolerate surgery and those with stage III or IV endometrial cancer who are not suitable for surgery, and it still has a certain effect. Radiotherapy should include intracavitary irradiation and external irradiation. Intracavitary irradiation often uses 137Cs, 60Co, etc., and external irradiation often uses 60Co and linear accelerators. Ra has been abandoned.

4. Chemotherapy

Chemotherapy can be considered for patients with advanced endometrial cancer who cannot undergo surgery or who relapse after treatment. Commonly used chemotherapy drugs include doxorubicin, fluorouracil (5-FU), cyclophosphamide (CTX), mitomycin (MMC), etc.; they can be used alone, in combination with several drugs, or in combination with progesterone.

The above article is a detailed introduction to "What are the treatments for endometrial cancer?" I believe that you will understand it after reading it. It is not difficult to cure endometrial cancer as long as the patient follows the principle of symptomatic treatment. I hope the above article can help everyone.