Who may be at high risk of colon cancer

In recent years, the evidence of genetic factors involved in colorectal cancer is increasing. The American Cancer Society believes that high-risk groups should be judged from two aspects: family history and personal history. The former includes a history of colorectal cancer in first- and second-degree relatives, a history of adenomatous polyposis and a history of family hereditary syndrome in first-degree relatives under the age of 60, mainly including familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal cancer (HNPCC), Turcot syndrome, Oldfield syndrome and juvenile polyposis; the latter includes a history of inflammatory bowel disease, adenomatous polyposis and a history of intestinal cancer, adenoma or other organ (breast, ovary, uterus and urinary system) cancer. At present, there is no unified standard for high-risk groups for colorectal cancer in China. .

The following are considered to be high-risk groups:

(1) People aged 30 to 40 years and above with gastrointestinal symptoms.

(2) Those with a history of colorectal cancer.

(3) Patients with precancerous lesions of colorectal cancer such as adenoma, ulcerative colitis, and schistosomiasis.

(4) Those with a family history of cancer, family history of polyposis, or hereditary colon disease.

(5) Patients with a history of pelvic radiotherapy.

(6) Those with a history of cholecystectomy or appendectomy.

Some domestic scholars believe that for people over 40 years old, those who have one of the following four items can be considered high-risk subjects for regular colonoscopy screening:

(1) Positive fecal occult blood test (FOBT) by immunoassay.

(2) A first-degree relative has a history of colorectal cancer.

(3) Patients with a history of cancer or intestinal polyps.

(4) Those with two or more of the following: chronic diarrhea, chronic constipation, bloody stools with mucus, chronic appendicitis, and history of mental stimulation.