Experts analyze the three most common causes of pancreatic cancer

Pancreatic cancer is a relatively common malignant tumor that endangers the lives and health of many people. What are the causes of pancreatic cancer ? Let the experts tell you about the common causes of pancreatic cancer.

In general, the common causes of pancreatic cancer are:

1. Smoking

A large number of studies support that the cause of pancreatic cancer is closely related to smoking. Possible mechanisms of pancreatic cancer caused by smoking: ① Smoking promotes the secretion of tobacco-specific N-nitrite, a carcinogen, into the bile duct, which then flows back into the pancreatic duct; ② The specific effect of tobacco-specific N-nitrite on the organ can flow into the pancreas with the blood; ③ Smoking increases blood lipid levels and promotes pancreatic cancer. Smokers may be prone to cancer due to low cell methylation levels. Experiments by Stolzenberg et al. confirmed that maintaining adequate folic acid and pyridoxal concentrations can reduce the risk of pancreatic cancer associated with smoking. This is a relatively common cause of pancreatic cancer.

2. Chronic pancreatitis

Most epidemiological and molecular epidemiological studies support that chronic pancreatitis can develop into pancreatic cancer. Friess's study showed that among 5,600 genes, 34 genes were expressed less in patients with pancreatic cancer and chronic pancreatitis, 157 genes were expressed more strongly in chronic pancreatitis, and 152 of them were also expressed more strongly in pancreatic cancer. This study proved at the molecular level that there may be some connection between chronic pancreatitis and the cause of pancreatic cancer.

3. Coffee

The survey found that coffee can increase the risk of pancreatic cancer by 4 times. Studies have shown that coffee can inhibit DNA repair and induce mitosis before DNA replication is completed, which is the main cause of pancreatic cancer.

The above is an introduction to the common causes of pancreatic cancer. I hope it will be helpful to everyone. Understanding and recognizing the causes of pancreatic cancer can help patients better accept pancreatic cancer treatment and help delay the disease.

For more information, please visit the pancreatic cancer disease special topic at http://www..com.cn/zhongliu/yxa/ or consult an expert for free. The expert will then give a detailed answer based on the patient's specific situation.