Particle implantation for the treatment of central lung tumors

In recent years, the incidence and death toll of malignant tumors have been rising, making malignant tumors the leading cause of death in my country. Central lung tumors grow at the hilum of the lungs and are often surrounded by large trachea and blood vessels. They are very difficult to treat, with rapid clinical symptoms. They are often not surgically resectable, and chemotherapy may even aggravate the condition. Particle implantation is a good treatment method.

Although there are many methods for treating tumors, tumors are complex diseases with various changes. Central lung tumors may involve the pulmonary artery or compress the trachea, and patients may have severe symptoms. The surgical risk for patients with central lung tumors is very high. Chemotherapy can eliminate subclinical lesions that are difficult to detect after surgery and perform systemic treatment on disseminated tumors, but its adverse reactions and cancer cell resistance have become the biggest obstacles to improving efficacy. At this time, a method that is both minimally invasive and can quickly kill tumors is needed.

The unique advantages of particle implantation - minimally invasive, continuous, and close-range - have achieved good results in clinical applications. For example, for patients with pleural metastasis of central lung tumors, firstly perform particle implantation on the primary lesion to prevent the primary lesion from metastasizing, and then perform interventional thermal chemotherapy on the metastatic lesion, which can effectively control the symptoms. If pleural effusion occurs, high-frequency hyperthermia in vitro can be used to promote the absorption of pleural effusion.

Particle implantation is a new tumor radiotherapy treatment method in recent years, called permanent in vivo radioactive particle implantation. It combines internal radiotherapy with minimally invasive surgery. Microparticles carrying radioactive rays are implanted into the tumor. The radioactive particles form a radiation field around it, preventing the biosynthesis of cell DNA and RNA, making all tumor cells lose their reproductive ability, thereby killing tumor cells to the maximum extent. The radioactive particles are a substance called iodine 125, 4.5 mm long and only 0.8 mm in diameter. The effective diameter of each particle is 1.7 cm.

During treatment, CT scanning is first used to locate the tumor. Based on the location of the tumor and the required radiation dose, iodine 125 is accurately implanted into the tumor through image monitoring. Multiple radioactive particles can be implanted at the same time according to the size of the tumor, evenly distributed in the tumor, forming radiation fields, destructively killing tumor cells, and thus achieving a more thorough treatment effect.

Currently, the most commonly used tumor to be treated with particle implantation is lung tumor. In fact, as long as the technology is advanced, tumors in many parts of the body can be treated with particle implantation.

Particle implantation is a minimally invasive surgery, with a wound of only about 1 cm in diameter. After the surgery, the wound can be sealed with a band-aid, which consumes very little energy from the patient, thus avoiding complications and contraindications caused by major surgical trauma. It is painless and patients can be discharged from the hospital after a few days of observation.

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