What factors are related to gallbladder cancer?

Gallbladder cancer ranks first among malignant tumors of the gallbladder. In the early stage of gallbladder cancer, there are no specific clinical manifestations or only symptoms of chronic cholecystitis. Early diagnosis is very difficult. Once persistent pain, mass, jaundice and other lesions appear in the upper abdomen, it is already in the late stage, and various examinations also show abnormalities. So what factors are related to gallbladder cancer?

The cause of gallbladder cancer is still unclear, but the following factors are related.

1. Ulcerative colitis

The incidence of biliary tumors in this type of patients is 10 times that of the general population, but the exact cause is unknown and may be related to changes in bile acid metabolism.

2. Abnormal common channel of bile duct

3. Gallbladder adenoma and adenomyomatous hyperplasia

Gallbladder adenoma is a benign tumor originating from the mucosal epithelium, but in recent years it has been found to have a high rate of canceration. Tumors larger than 10 mm, without sessile or with a wide base have a greater chance of canceration. The disease has now been basically identified as a precancerous lesion and is receiving increasing attention.

4. Gallstones

Many studies have suggested that gallstones are one of the important causes of gallbladder cancer, because the proportion of gallbladder cancer with gallstones is as high as 60%-100%, and the rate of gallbladder stone patients suffering from gallbladder cancer in the future can reach 3%-14%, which is several times higher than those without stones. Moreover, the larger the stone, the higher the risk of gallbladder cancer. It is generally believed that this is related to the long-term stimulation of gallstones on the gallbladder mucosa or the concurrent chronic inflammation leading to gallbladder mucosal hyperplasia, and then atypical hyperplasia and canceration.

5. Others

People who are frequently exposed to carcinogens, such as rubber workers, have a higher incidence of gallbladder cancer. There are also reports that abnormal cholesterol metabolism, estrogen and obesity are associated with the incidence of gallbladder cancer, but further research and confirmation is needed.

The above is an introduction to the causes of gallbladder cancer. I believe that everyone has a general understanding of the causes of gallbladder cancer. I hope it can be helpful to everyone. If you have any other needs, you can also consult our online consulting experts. We are always available to answer your questions and give you more detailed guidance. Feihua Health Network wishes you good health!

Gallbladder cancer http://www..com.cn/zhongliu/dna/