Anti-ribonucleoprotein antibody positive

Antibodies are indispensable substances in the human body. Only with antibodies can the body be in a state of automatic defense and keep various diseases out. The abilities of various antibodies vary. Among them, anti-ribonucleoprotein antibodies are core antibodies, which have a great impact on physical health. Let’s take a look at the significance of positive anti-ribonucleoprotein antibodies. I hope everyone can understand it.

Anti-ribonucleoprotein antibodies, also known as anti-RNP antibodies, are a group of autoantibodies and also belong to antinuclear antibodies. It occurs in 35% to 45% of patients with systemic lupus erythematosus and 95% to 100% of patients with mixed connective tissue disease, a disorder that has features of myositis, lupus erythematosus, and scleroderma. The detection rate of anti-RNP antibodies is not high in other autoimmune diseases. Its detection methods include immunoblotting, indirect immunofluorescence and enzyme-linked immunosorbent assay. As a marker antibody, it is important in the diagnosis and differential diagnosis of lupus erythematosus and mixed connective tissue disease, but it has nothing to do with the activity and stability of the disease.

Clinical significance:

Anti-ribonucleoprotein antibodies are found in 35% to 45% of patients with systemic lupus erythematosus, and this autoantibody is found in almost all patients with mixed connective tissue disease. Therefore, if anti-ribonucleoprotein antibodies are positive, they can be seen in mixed connective tissue disease, systemic lupus erythematosus, rheumatoid arthritis, progressive systemic sclerosis, and dermatomyositis.

1. High titer: mixed connective tissue disease (MCTD).

2. Low titer: various rheumatic diseases, progressive systemic sclerosis (PSS), dermatomyositis.

Anti-SM antibodies are specific antibodies for patients with systemic lupus erythematosus. 30% of patients with lupus erythematosus test positive for anti-SM antibodies. And this antibody can exist regardless of whether the disease is in the active stage. In addition to some patients with systemic lupus erythematosus who have SM antibodies, SM antibodies can also be found in patients with complex connective tissue disease. Other items need to be actively checked to confirm the diagnosis and receive early treatment.

It is recommended to check anti-SM antibodies and anti-DSA antibodies. If these two antibodies are positive, systemic lupus erythematosus can be confirmed. Your condition is similar to lupus and you can take hormone diagnostic treatment.