Hormone-sensitive lipase

Many people have not heard of hormone-sensitive lipase, but everyone has heard of hormones. In fact, hormones and hormone-sensitive lipase are completely different. Moreover, hormone-sensitive lipase is an element mainly secreted by some relatively developed tissues such as testicular muscles and adrenal glands. It plays an important structural role in the body. Let's take a look at the detailed introduction of hormone-sensitive lipase.

Introduction

Hormone-sensitive triglayceride lipase (HSL) is the rate-limiting enzyme for lipolysis and is regulated by multiple hormones. Hormones that promote fat mobilization are called lipolytic hormones, such as adrenaline, glucagon, ACTH and TSH; hormones that inhibit fat mobilization, such as insulin, prostaglandin E2 and hydrochloric acid, are called anti-lipolytic hormones.

HSL is mainly secreted by adipose tissue and is also found in tissues such as the pancreas, testicles, muscles, and adrenal glands. HSL is an intracellular neutral lipase with relatively weak specificity. It can hydrolyze triglycerides, diglycerides, monoglycerides and cholesteryl esters, but has no phospholipase hydrolysis activity.

With the knockout of HSL gene, the fat hydrolysis ability is destroyed, and the lipid synthesis and fat metabolism ability are significantly reduced, which shows that HSL plays an irreplaceable role in the synthesis and catabolism of fat.

At the beginning of exercise, HSL activation participates in the hydrolysis of working muscle fat, which is also the main reason for the increase in fat hydrolysis caused by exercise.

Hormone-sensitive triglyceride lipase

(Abbreviation: HSL) plays a decisive role in fat mobilization and is the rate-limiting enzyme in fat decomposition. Its activated form is the phosphorylated form, which can directly act on fat to hydrolyze triglycerides into diglycerides. HSL is regulated by a variety of hormones, so it is called the phosphorylated form of hormones. It can directly act on fat to hydrolyze triglycerides into diglycerides. HSL is regulated by multiple hormones, so it is called hormone-sensitive lipase. Can promote fat-sensitive lipase. Hormones that promote fat mobilization are called lipolytic hormones.

Insulin and prostaglandins can inhibit its activity and are called anti-lipolytic hormones; glucagon, adrenaline, adrenocorticotropic hormone and thyroxine promote its activity and are called lipolytic hormones.

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