Normal value of carbohydrate antigen 153

CA153 is a carbohydrate antigen. Generally, the normal value and test value of CA153 are compared to judge tumors, cancer and other related diseases. It is mainly used for female-related diseases, such as breast cancer, cervical cancer, breast hyperplasia, ovarian cysts, gynecological inflammation, etc. At the same time, the hospital will cooperate with other examination items to rule out malignant diseases. The editor will briefly introduce carbohydrate antigen 153.

CA15-3 is the most important specific marker for breast cancer. 30%-50% of breast cancer patients have significantly elevated CA15-3 levels, and changes in its content are closely related to the treatment effect. It is the best indicator for diagnosing breast cancer patients, monitoring postoperative recurrence, and observing therapeutic effects. Dynamic measurement of CA15-3 helps to detect early recurrence of stage II and stage III breast cancer patients after treatment; when CA15-3 is greater than 100U/ml, it can be considered that there is metastatic lesion.

Carbohydrate Antigen System

In the 1980s, experts used hybridoma technology to obtain the ability to recognize tumor-specific large molecular glycoprotein antigens (carbohydrate antigen, CA) and developed a monoclonal antibody recognition system. CA is a tumor cell-associated antigen. Commonly used CA series include: CA 125 (ovarian cancer-related antigen); CA 19-9 (pancreatic and intestinal cancer-related antigen); CA 15-3 (breast cancer-related antigen). CA153 is a breast cancer-related antigen and has certain value in the diagnosis and postoperative follow-up of breast cancer. CA153 is often elevated in breast cancer, but its sensitivity is low in the early stages of breast cancer, at about 60%. The positive rate of metastatic breast cancer can reach 80%. In Europe, CA153 is often used as an auxiliary diagnostic indicator for breast cancer, and is also used for postoperative follow-up to monitor tumor recurrence and metastasis. However, other tumors such as lung cancer, kidney cancer, colon cancer, pancreatic cancer, ovarian cancer, liver cancer, etc. may also increase to varying degrees. But the significance of CA153 in these tumors Clinical significance Edit Carbohydrate antigen 15-3 (CA15-3) quantifies the concentration of glycoprotein CA15-3 (Breast Cancer Antigen CA15-3) in human serum or plasma by chemiluminescent enzyme immunoassay. Increased levels are seen in breast cancer and are often used to observe the efficacy of treatment and estimate prognosis for breast cancer. It may also increase to varying degrees in metastatic ovarian cancer, colon cancer, liver cancer, bile duct cancer, pancreatic cancer, lung cancer and bronchial cancer. In the 1880s, it had certain value in the diagnosis and treatment follow-up of breast cancer, but its low sensitivity in the early stages of breast cancer was its shortcoming. Generally, the reference value of CA15-3 is <28U/ml.

Clinical Application:

(1) CA15-3 is elevated in breast cancer patients. The sensitivity of early-stage breast cancer is 60%, and the sensitivity of late-stage breast cancer is 80%. CA15-3 is of great value in the observation of therapeutic efficacy, prognosis judgment, and diagnosis of recurrence and metastasis of breast cancer.

(2) Other malignant tumors also have a certain positive rate. Such as: lung cancer, colon cancer, pancreatic cancer, ovarian cancer, cervical cancer, primary liver cancer, etc.

(3) For non-malignant tumor diseases such as liver, gastrointestinal tract, lung, breast, and ovary, the positive rate is generally <10%. In addition, breast cancer patients with elevated CA15-3 levels develop metastasis much earlier than those with normal CA15-3 levels. According to analysis and research, there is consistency between the changes in serum CA15-3 levels in breast cancer patients and their local lymph nodes and distant metastasis. In particular, those with distant metastases have significantly increased CA15-3 expression levels and positivity rates. Therefore, CA15-3 plays a monitoring role in breast cancer metastasis. If its serum level continues to rise, chemotherapy, radiotherapy, or endocrine therapy should be started or strengthened.

Whether you are ill

If CA15-3 is elevated, further examination may be necessary to rule out the possibility of a tumor. However, the specificity of these indicators is not high and there are many influencing factors. Therefore, they are mainly used for preliminary screening of tumors in clinical practice and cannot be used to confirm the diagnosis of tumors.