What disease is caused by unequal pupils

We all know that eyes are very important to our body. Because of their importance, many people suffer from eye diseases of one kind or another. Moreover, eye diseases are relatively minor, so the success rate of cure is generally not very high, so we must protect our eyes well in life. But we have also seen the pupils in the eyes. Sometimes there are some problems with the pupils. In certain circumstances, they can reflect the quality of our eyes, or whether the eyes need medical treatment for correction. For example, what diseases are common causes of unequal pupils? So let's understand what is going on with unequal pupils!

1. Causes

1. Dilated pupil. Unilateral dilated pupil can be seen in oculomotor nerve damage, hippocampal uncus herniation or sympathetic nerve stimulation, eye trauma, decreased vision, etc. Bilateral mydriasis can be seen in midbrain lesions, infectious diseases of the central nervous system, cerebrovascular disease, cerebral hypoxia, brain tumors, craniocerebral trauma, drug poisoning (such as atropine, etc.), pain, fear, hyperthyroidism, congenital abnormalities, etc.

2. Pupil constriction. Pupil constriction can be seen in stimulation of the oculomotor nerve, damage to the cervical sympathetic nerves, foreign bodies in the cornea or the eye, etc. The pupils on both sides are constricted, which can be seen in infants and the elderly. Syphilis, pontine lesions, cerebrovascular disease, drug poisoning (morphine poisoning), organophosphorus poisoning, etc.

3. Anisocoria, unilateral oculomotor nerve paralysis, skull base lesions, cerebral or midbrain lesions, sympathetic nerve paralysis, etc.

II. Medical History

Patients with pupil abnormalities rarely discover them on their own. They are often discovered by others or when looking in the mirror. Attention should be paid to the time of discovery, whether it is continuous or intermittent, how it is discovered, whether the disease progresses quickly or slowly, whether it occurs in one eye or both eyes, or alternately, etc.

When collecting the medical history of pupil abnormalities, attention should be paid to systemic diseases such as hypertension, which may cause aneurysms, arteriosclerosis, cerebrovascular disease, diabetes, syphilis, hyperthyroidism, and a history of chronic alcoholism, which are factors that are prone to complications of extraocular muscle paralysis. Also pay attention to neck diseases, lung diseases, pharyngeal diseases, history of brain trauma and tumors, etc.

History of drug use: for example, drugs that dilate the pupil include atropine, scopolamine, belladonna, adrenaline, etc.; factors that constrict the pupil include organophosphorus poisoning, cervical sympathetic nerve paralysis, pontine lesions, etc. Also pay attention to whether there is any ophthalmic examination or treatment of mydriasis or miosis.

Pay attention to asking about neurological conditions such as headaches, nausea, vomiting, cerebrovascular disease, brain tumors, facial sweating, and whether vision is clear.

3. Physical Examination

1. Pay attention to body temperature during general examination. Fever is mostly caused by infectious diseases such as cavernous sinus thrombosis, encephalitis, and meningitis; proptosis can be seen in cavernous sinus thrombosis, orbital tumors, and carotid cavernous sinus fistula; bruits in the eyes are caused by carotid cavernous sinus fistula; trauma to the eyes, neck, or brain; and whether there are tumors, inflammation, or swollen lymph nodes in the neck and pharynx.

2. Whether the pupil is dilated or constricted, unilateral or bilateral, direct and indirect light reflex, size of palpebral fissure, whether the eyeball is protruding or congested, whether the eye movement function is affected, vision and visual field, whether there is diplopia, abnormal eye movement and convergence, etc., facial movement, sensation and sweating on the same side, and whether there is papilledema, congestion and atrophy of the fundus. Other localizing signs of the nervous system include limb paralysis, paresthesia, autonomic nervous system dysfunction, etc.

4. Auxiliary examination

1. CT or MRI of the brain or eyes: Check for brain tumors, inflammation, thrombosis, vascular malformations, brainstem lesions, syringobulbar disease, orbital tumors, inflammation, etc.

2. Spinal cord MRI: Check for syringomyelia, tumors, inflammation, etc.

3. Thyroid examination, blood sugar test, X-ray examination of the neck, lungs and pharynx, and histopathological examination, etc.