Hazards of iopromide contrast agent

Iopromide contrast agent is a contrast agent used when performing arterial angiography or venography on patients. From a clinical point of view, it is particularly suitable for cardiovascular angiography and can make the examination results clearer. However, it also has a bad side and can cause certain harm to patients. For example, some patients may experience cerebral infarction, arrhythmia, heart failure, and even shock and death. It can be seen that once these abnormalities occur, they must be treated as soon as possible.

1. Indications of iopromide contrast agent

For diagnostic medication. Iopromide injection 300 (iodine concentration 300mg/ml) is used for intravascular and body cavity administration. Contrast-enhanced computed tomography (CT), arteriography and venography, arterial/venous digital subtraction angiography (DSA), intravenous urography, endoscopic retrograde cholangiopancreatography (ERCP), arthrography, and other body cavity examinations cannot be used intrathecally. Iopromide injection 370 (iodine concentration 370 mg/ml) is used for intravascular and body cavity administration. Computerized tomography (CT) enhancement, arterial and venographic angiography, arterial/venous digital subtraction angiography (DSA), especially suitable for cardiovascular angiography, intravenous urography, endoscopic retrograde cholangiopancreatography (ERCP), arthrography and other body cavity examinations, cannot be used within the sheath.

2. Hazards of iopromide contrast agent

The most serious adverse drug reactions occurring in patients taking this product (with life-threatening and/or fatal case reports during clinical trials or post-marketing surveillance) include: anaphylactic shock, respiratory arrest, bronchospasm, laryngeal edema, pharyngeal edema, asthma, coma, cerebral infarction, stroke, cerebral edema, convulsions, arrhythmia, cardiac arrest, myocardial ischemia, myocardial infarction, heart failure, bradycardia, cyanosis, hypotension, shock, dyspnea, pulmonary edema, respiratory insufficiency and aspiration.

3. Contraindications of using iopromide contrast agent

It is contraindicated in patients who are allergic to iodinated contrast media or have significant hyperthyroidism. Hysterosalpingography is contraindicated in pregnant women and patients with acute pelvic inflammatory disease. ERCP (endoscopic retrograde cholangiopancreatography) is contraindicated in patients with acute pancreatitis. Contraindicated for intrathecal injection. Intrathecal administration may result in death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia and cerebral edema, chemical meningitis, and meningitis pseudoepilepticus.