The difference between cryoprecipitate and plasma

Everyone knows what blood is, but many people are not sure what words like plasma and cryoprecipitate mean. For hemophilia patients, fresh plasma and cryoprecipitate are needed when receiving blood transfusions. Sometimes cryoprecipitate is also used for post-operative bleeding or severe trauma. Cryoprecipitate is also used in the treatment process, and if the cryoprecipitate is kept in a frozen state, its validity period will reach 1 year.

Difference Between Cryoprecipitate and Plasma

1. Fresh frozen plasma contains all coagulation factors and is mainly used for supplementary treatment of patients with various coagulation factor deficiencies; ordinary frozen plasma contains all stable coagulation factors, but lacks unstable coagulation factors VIII and V, and is mainly used for the treatment of patients with factor deficiencies other than coagulation factors VIII and V.

2. Cryoprecipitate contains 5 main components:

Rich in factor VIII (about 10 times the concentration of factor VIII in fresh frozen plasma), fibrinogen, von Willebrand factor (vWF), fibronectin (fibronectin) and factor XIII.

Cryoprecipitate

Indications for cryoprecipitate

1. Congenital or acquired fibrinogen deficiency: For fibrinogen deficiency caused by severe trauma, burns, leukemia and liver failure, infusion of cryoprecipitate can significantly improve the prognosis.

2. Congenital or acquired coagulation factor VIII deficiency: Since cryoprecipitate contains a relatively rich amount of FVIII, it is often used as a substitute for FVIII concentrate.

3. Von Willebrand disease (vWD): Von Willebrand disease is characterized by a lack or defect of vWF in plasma. Because cryoprecipitate contains high levels of FⅧ and vWF, cryoprecipitate is the most ideal preparation for vWD replacement therapy.

4. Children and mild adults with hemophilia A: The treatment of hemophilia A mainly relies on FVIII supplementation. Cryoprecipitate is one of the most effective preparations besides FVIII concentrate.

5. Cold precipitate contains fibronectin (Fn). Postoperative infusion can make the wound heal quickly and smoothly.

6. Hypovolemic shock complicated by DIC.

Cryoprecipitate dosage

The commonly used dose is: 1 to 1.5 units per 10 kg body weight.

Cryoprecipitation precautions

1. Blood transfusion should be based on the ABO blood type compatibility principle, and cross matching is not required.

2. Before infusion, the tube should be thawed in a 37°C water bath within 10 minutes. During the thawing process, it must be gently shaken to avoid excessive local temperature.

3. The thawed cold precipitate should be transfused as soon as possible within 4 hours and should not be re-frozen.