What should I pay attention to when injecting sodium bisulfite and menadione

In life, many newborn babies have bleeding or vitamin K deficiency caused by intestinal malabsorption. These conditions can be effectively alleviated by sodium bisulfite menadione injection, and sodium bisulfite menadione injection can also treat hypoprothrombinemia. Sodium bisulfite menadione injection is a colorless, clear liquid that is easily decomposed when exposed to light. So what should be paid attention to when injecting sodium bisulfite menadione?

First, what should be paid attention to when injecting sodium bisulfite and menadione? Hemostasis: 2-4 mg intramuscular injection once, 4-8 mg a day; to prevent neonatal hemorrhage, pregnant women can be given intramuscular injections one week before delivery, 2-4 mg a day. Antispasmodic and analgesic: intramuscular injection, 8 to 16 mg each time. Common side effects include: local redness, swelling and pain. Larger doses can cause hemolytic anemia, hyperbilirubinemia and jaundice in newborns and premature infants. In patients with erythrocyte 6-phosphate dehydrogenase deficiency, acute hemolytic anemia may be induced. Large doses can cause liver damage. Patients with impaired liver function can use vitamin K1 instead.

Second, vitamin K carries the risk of allergic reactions. When patients suffer from severe bleeding due to vitamin K-dependent factor deficiency, short-term application is often not enough to take effect immediately, and prothrombin complex, plasma or fresh blood can be infused intravenously first. This product is a vitamin medicine. Vitamin K is an essential substance for the liver to synthesize factors II, VII, IX, and X. Vitamin K deficiency can cause synthesis disorders or abnormalities of these coagulation factors, which can be seen clinically as bleeding tendency and prolonged prothrombin time. After intramuscular injection and absorption, it is transported with β-lipoprotein and its effect begins to become obvious after about 8 to 24 hours. It is then used in the liver and it takes several days for prothrombin to return to normal levels. It is excreted through the kidneys and bile duct in the form of glucuronic acid and sulfate conjugates.

What should be paid attention to when injecting sodium bisulfite and menadione? When used to correct hypoprothrombinemia caused by oral anticoagulants, the minimum effective dose should be tried first and then adjusted based on the prothrombin time measurement; excessive vitamin K can make subsequent continuous anticoagulant treatment difficult. This product is ineffective for patients with bleeding in patients with cirrhosis or advanced liver disease, as well as bleeding caused by heparin.