Indapamide sustained-release tablets

Some people with mild hypertension, diastolic hypertension, may have symptoms such as dizziness and headache, which are often caused by genetic factors. A high-salt diet can aggravate the symptoms. Indapamide sustained-release tablets are a good long-acting drug for the treatment of hypertension. They can be taken orally for a long time. Due to the gradual cumulative effect of the drug, the patient's blood pressure can gradually decrease. Therefore, we should follow the doctor's advice and take medications regularly, eat a low-salt, low-fat, high-fiber diet, and exercise moderately to keep blood pressure stable. If necessary, we can choose to change medications. Treatment requires treatment under the guidance of a doctor. Now let's take a look at Indapamide sustained-release tablets!

1. Indications: essential hypertension.

2. Usage and Dosage

oral. Take 1 tablet every 24 hours, preferably in the morning. Swallow the tablet whole with water without chewing it. Increasing the dose does not improve the antihypertensive effect of indapamide, but can only increase the diuretic effect.

3. Adverse Reactions

Most clinical and laboratory adverse reactions were dose-dependent. Thiazides and related diuretics including indapamide may cause the following: Effects on the blood and lymphatic circulatory system -

Rare: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia Effects on the nervous system - Uncommon: dizziness, fatigue, headache, paresthesia Effects on the heart -

Rare: cardiac arrhythmias, hypotension. Gastrointestinal effects - Rare: nausea, constipation, dry mouth - Rare: pancreatitis. Hepatobiliary effects - Hepatic encephalopathy may occur in patients with liver failure. - Rare: Changes in liver function

Effects on skin and tissues - Allergic reactions, mainly skin allergies (usually maculopapular rashes, a few with purpura), are common in patients with previous allergies and asthma. -

It may aggravate existing acute systemic lupus erythematosus.

4. Laboratory parameters:

1. In clinical trials, hypokalemia was observed: after 4 to 6 weeks of treatment, 10% of patients had a blood potassium concentration less than 3.4mmol/l, and 4% of patients had a blood potassium concentration less than 3.2mmol/l. After 12 weeks of treatment, the average blood potassium concentration of patients decreased by 0.23mmol/l.

2. Potassium loss associated with hypokalemia is particularly serious in certain high-risk groups (see [Precautions])

3. Hyponatremia with hypovolemia will cause dehydration and orthostatic hypotension. Concomitant chloride loss can lead to secondary compensatory metabolic alkali poisoning: this reaction is rare and mild.

4. During treatment, plasma uric acid and blood glucose increase: These diuretics must be evaluated very carefully when used in patients with gout and diabetes.

5. Hypercalcemia

5. Taboo

1. Allergy to sulfa drugs.

2. Severe renal failure.

3. Hepatic encephalopathy or severe liver failure.

4. Hypokalemia.

6. Notes

WARNING: Thiazides and related diuretics may cause hepatic encephalopathy when liver function is impaired. If this occurs, diuretics should be stopped immediately.

Because this medicine contains lactose, it is contraindicated in patients with congenital galactosemia, glucose and galactose malabsorption, or lactase deficiency. Note: Water and electrolyte balance - blood sodium

Serum sodium must be measured before treatment and should be monitored regularly thereafter. Any diuretic therapy may result in hyponatremia, sometimes with serious consequences. Decreased serum sodium may be asymptomatic initially, so regular monitoring of serum sodium is essential; in the elderly and patients with cirrhosis, monitoring should be more frequent (see Adverse Reactions and Overdosage).

- Serum potassium

Hypokalemia due to potassium wasting is the major risk of thiazide and related diuretics. In certain high-risk groups, such as the elderly, those who are malnourished and/or on polypharmacy, and patients with cirrhosis, CAD and heart failure with edema and ascites, the development of hypokalemia (< 3.4 mmol/l) must be prevented. In these cases, hypokalemia can increase the cardiotoxicity of digitalis and increase the risk of arrhythmias.

Patients with a long QT interval in the electrocardiogram, whether congenital or iatrogenic, are at risk for using this drug. Hypokalemia and bradycardia are both precipitating factors for serious arrhythmias (especially the potentially fatal torsades de pointes). In all of the above cases, increased potassium monitoring is necessary. The first serum potassium measurement should be performed within 1 week of starting treatment. Once hypokalemia is detected, appropriate corrections should be made.

- Serum calcium

Thiazides and related diuretics may decrease urinary calcium excretion, causing a transient, mild increase in serum calcium. Overt hypercalcemia may be due to previously unrecognized hyperparathyroidism. Treatment should be discontinued until parathyroid function is checked. -

Blood glucose monitoring is very important in diabetic patients, especially when hypokalemia is present. - Uric acid Patients with hyperuricemia may have an increased risk of gout attacks and should be careful to monitor the uric acid level in their blood. -

Renal function and diuretics are only effective when renal function is normal or mildly impaired (serum creatinine is less than 25 mg/L in adults, i.e. 220 µL).

mol/L), thiazide and related diuretics can fully exert their effects. In the elderly, serum creatinine values ​​must be adjusted for age, weight, and sex using Cockroft's formula:

Clcr=(140-age)×weight/(0.814×serum creatinine) Where: Age is calculated in years Weight unit: kg Serum creatinine is expressed in micromoles/liter

This formula is suitable for elderly men. For female patients, the result should be multiplied by 0.85.

In the early stages of diuretic treatment, hypovolemia caused by water and sodium loss reduces glomerular filtration, which may lead to an increase in blood urea and creatinine. This transient functional renal insufficiency has no effect on people with normal renal function, but for those with renal insufficiency, it may further deteriorate renal function.

- Athletes should be aware that this medicine contains active ingredients that may cause a positive reaction in a doping test. Athletes should use with caution. Effects on ability to drive a motor vehicle and operate machinery

This product does not affect vigilance, but some patients may experience individual reactions related to lowering of blood pressure, especially at the beginning of treatment and when used in combination with other antihypertensive drugs.

This may result in a reduction in the ability of the person to drive a motor vehicle and operate machinery.

7. Use of the drug by pregnant and lactating women

Diuretics during pregnancy can cause placental ischemia and lead to fetal malnutrition. As a general rule, thiazide and related diuretics should be avoided in pregnant women and should never be used to treat physiologic edema of pregnancy. Lactation

Because the drug may enter breast milk, breastfeeding women should avoid taking this product.