Why does the big toe nail turn black?

Many patients with blood-related diseases choose to take hydroxyurea for treatment because it is the main drug for treating blood diseases. However, some patients find that their nails turn black after long-term use. Therefore, if patients experience this situation, they should seek medical treatment in time to avoid unnecessary trouble.

1. Hydroxyurea

Hydroxyurea is a mainstream drug in hematology clinical practice and is mostly used to treat myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia and chronic myeloid leukemia.

2. Common side effects of hydroxyurea in treatment

①: It can cause leukopenia and thrombocytopenia, which can be recovered 1 to 2 weeks after stopping the drug;

②: Gastrointestinal reactions may occur sometimes, and there are also risks of testicular atrophy and teratogenicity;

③: Occasionally, central nervous system symptoms and hair loss occur. There are also reports of drug-induced fever caused by this drug, which may recur when the drug is administered repeatedly.

Polycythemia vera, long-term overdose of hydroxyurea can cause black nails.

This is not an isolated case. Side effects often occur in patients, but if the dosage is reduced and the duration of medication is shortened, the blackening of nails will be improved.

It can be seen from this that oral medications such as hydroxyurea are still toxic. If it is impossible to reduce the dosage or stop taking the medication due to the need to treat the disease, it is recommended to promptly intervene with Chinese medicine treatment, which can improve side effects, reduce toxic side effects, and promote and help the treatment of the disease.