What medicine should I take for gonorrhea? Introduction to treatment methods

If gonorrhea is without complications, the medication is relatively simple, especially for gonorrhea in the early stages. The treatment is effective and fast. Taking the medication for a certain period of time as prescribed by the doctor can help improve gonorrhea. The treatment period for gonorrhea is relatively long, but it can be cured as long as the correct treatment method is used and active cooperation is provided.

Rifamycins

It has strong effects on both gram-negative and gram-positive bacteria, and is effective against infections with Mycobacterium leprae, viruses, and Chlamydia. Commonly used drugs include rifampin and rifamdin.

Penicillins

It kills bacteria by destroying bacterial wall synthesis. This type of drug is suitable for treating gonorrhea caused by non-penicillinase-resistant gonococci (ppng) and is the "standard treatment" for this disease. However, it is inappropriate to use it as a routine treatment without performing drug sensitivity testing before treatment. When the prevalence of ppng strains is greater than five percent, penicillin treatment should not be used, but other preparations should be used. The purpose of taking probenecid is to slow down the excretion of penicillin from the kidneys, reduce its binding to plasma proteins, increase blood levels, and prolong its half-life so as to fully exert its antibacterial effect.

Aminoglycosides and aminocyclic sugar alcohols

The main function is to inhibit bacterial protein synthesis. For the treatment of patients with penicillin resistance or allergy. Commonly used drugs in the former category include gentamycin, kanamycin, amikacin (amikacin) and netilmicin (ethyl); the latter category of drugs mainly includes spectinomycin (Linbizhi), which has a cure rate of over 98% for simple gonorrhea caused by ppng strains and non-ppng strains, and also has excellent efficacy for gonorrhea with complications; moreover, this drug does not produce cross-resistance with penicillins and cephalosporins, is safe to use, and is one of the best drugs for the treatment of gonorrhea.

Cephalosporins

It has the function of destroying bacterial wall and inhibiting bacterial protein synthesis. Although they are also antibiotics containing a beta-lactam ring, they are relatively stable or very stable to beta-lactamase. Therefore, they can often effectively replace penicillins for gonorrhea caused by ppng strains and chromosome-mediated resistant strains. The emergence of spectinomycin-resistant strains makes them viable alternatives.

Tetracyclines

It works by inhibiting the biosynthesis of bacterial proteins. It also has a good effect on gonorrhea, but it is not used as a first-line drug. Commonly used ones include tetracycline, doxycycline (doxycycline) and minocycline (minocycline).

Macrolides

Inhibit the biosynthesis of bacterial proteins. It is not used as a first-line drug, but mainly as an alternative to tetracyclines. Recent reports have shown that a single dose of azithromycin (1.0 g) has a cure rate of 96.4% for uncomplicated gonorrhea and a cure rate of 100% for concurrent chlamydia infection.

Chloramphenicol

Inhibit the biosynthesis of bacterial proteins. A single dose of 2.5 g of thiamphenicol is commonly used, and the cure rate for uncomplicated gonorrhea is 93%.

Lincomycins

It has high tissue concentration in the body, low toxicity, is safe, and is effective against anaerobic bacteria. Clindamycin is commonly used to treat pelvic inflammatory disease.