What are the symptoms of Hashimoto's encephalopathy?

Many people do not understand Hashimoto's encephalopathy. In fact, it is a disease caused by immune inflammatory response involving the blood-brain barrier. It often manifests as epileptic seizures, or symptoms of myoclonus and tremor, so we must pay attention to the occurrence of these symptoms.

1. Etiology and pathogenesis

Some scholars have proposed the theory of vasogenic edema: due to the immune inflammatory response involving the blood-brain barrier, the blood-brain barrier is damaged, resulting in multiple focal edema in the brain or diffuse cerebral edema, which can involve the brainstem and cortex, resulting in clinical symptoms such as focal neurological deficits or coma, which can be quickly relieved with the use of hormones.

2. Clinical manifestations

There are mainly two forms: 1. Vasculitis type characterized by multiple stroke-like attacks. 2. Diffuse progressive type characterized by dementia and mental symptoms. Both of the above forms may cause epileptic seizures, myoclonus, tremor and stupor. The former has a more acute onset, while the latter has a slower onset.

3. Diagnostic criteria

Unexplained paroxysmal recurrent myoclonic seizures, generalized epileptic seizures, focal neurologic deficits, or psychiatric disturbances.

At least three of the following five items are met

Abnormal EEG

Anti-thyroid microsomal antibodies increased

Increased CSF protein or oligoclonal bands

Responds well to corticosteroids

No abnormalities were found in the head MRI

4. Treatment methods

Neural targeted repair therapy uses the NS targeted positioning therapy device to accurately determine the treatment site without damaging normal neurons, allowing nerve growth factor to act on the damaged site quickly, effectively and directly through intervention. Its therapeutic effect is progressive and mutually reinforcing, and its mechanism of action is also gradual.