What is the normal percentage of alkaliphils?

Speaking of alkaliphilic cells, I believe many people are very unfamiliar with them. For some people who are not medical professionals, it is difficult to come into contact with such terms in daily life. But even though we don't know, there are still some people who are suffering from it, or some doctors are researching cures for such diseases. For us, only when many indicators of our body are within the normal range can we live a healthier life. What is the normal percentage of alkaliphils?

Alkaliphilic granulocytes originate from hematopoietic pluripotent stem cells in the bone marrow and enter the bloodstream after differentiation and maturation in the bone marrow. The origin of mast cells is still controversial. Currently, the origin of human mast cells and the relationship between mast cells and alkaliphils remain unclear. It is known that α-rat mast cells originate from hematopoietic pluripotent stem cells in the bone marrow and mature in the microenvironment of various tissues to form connective tissue mast cells and mucosal mast cells. Connective tissue mast cells are larger in size, have more cytoplasmic granules, higher histamine content, and are more sensitive to drugs.

Morphological structure

Alkaliphilic granulocytes are round, with a diameter of 10 to 14 μm. The nucleus is not clearly lobed, and the cytoplasm contains alkaliphilic granules of irregular shapes and varying sizes. When stained with toluidine blue, the granules turn from blue to purple, which is called metachromasia. The diameter of large granules can reach 1.2 μm and they are easily soluble in water. Under an electron microscope, the electron density of the particles is high. The cytoplasm has complex vesicles and is rich in glycogen. Other organelles are not obvious.

Reference value

Normal reference value

Percentage 0～0.01 or (0%—1%)

Absolute value 0～0.1 10^9/L

Abnormal result analysis

Alkali neutrophilia:

Alkaliphilic leukemia (rare) and chronic myeloid leukemia are often accompanied by an increase in alkaliphilic granulocytes. An increase in alkaliphilic granulocytes can also be seen in myelofibrosis, chronic hemolysis, and after splenectomy.

Alkaliphilopenia:

① Type I hypersensitivity reaction (immediate allergic reaction), such as urticaria, anaphylactic shock, etc.; excessive adrenocorticotropic hormone and glucocorticoids; hyperthyroidism; Cushing's disease, etc.;

② Stress response, such as myocardial infarction, severe infection, bleeding, etc.

We have physical examinations every year, and each time the doctor will give us some test reports with many examination indicators on them. Alkali basophils can make certain judgments about our health status. Sometimes we don’t quite understand some indicators. In order to understand them clearly, we must learn some knowledge in this area. Please remember what the editor has introduced.