Causes of stiff and painful back

Many people suffer from back stiffness and pain for various reasons, so if it exists for a long time, it will seriously affect their physical health. Therefore, for many people who pursue health, in order to recover as soon as possible, they want to understand the causes of back stiffness and pain. The following is an introduction in this regard. For many friends who want to fully understand the reasons, you can continue to read the introduction below.

1. Causes of disease

This disease is a rare autosomal genetic disease. The exact autosomal variant is unknown.

2. Pathogenesis

Homogentisate (HGA or 2,5-dihydroxyphenylacetic acid) is the last compound in the metabolic pathway that contains a complete aromatic ring in the conversion of phenylalanine and tyrosine to acetoacetate. The enzyme that catalyzes the cleavage of the aromatic ring is homogentisate oxidase, which is normally present in the soluble parts of liver and kidney tissues. This enzyme is highly specific for the breakdown of homogentisate and is not found in tissues other than the liver and kidneys. In patients with this disease, the activity of this enzyme is completely lacking in the liver and kidneys, resulting in the inability of homogentisate to be broken down into acetoacetate and fumarate. This requires the use of other metabolic mechanisms to process homogentisate. The kidneys have a high clearance rate for homogentisic acid, and the renal tubules actively secrete homogentisic acid. Once the kidneys excrete homogentisic acid from the body, it will gradually oxidize to form polymers that can cause urine discoloration.

The mechanism by which homogentisate deposits in tissues and causes ochronosis is still unclear. Homogentisate has a tendency to deposit in the skin and cartilage, where it is bound by physical attraction. In addition, the decomposition products of homogentisic acid can irreversibly bind to connective tissue to form polymers that can cause pigmentation. The tissue becomes brittle after staining and may even break, leading to degenerative changes in the intervertebral discs and joints. In addition, homogentisate can also directly act on collagen synthesis by inhibiting lysyl hydroxylase.

Pathology: Blackening of connective tissue and cartilage is the basic pathological change of this disease. Homogentisate can be deposited in organs such as the skin, cornea, cartilage, tendons, ligaments, endothelium of large blood vessels, endocardium, thyroid gland, lungs and kidneys, causing the tissues of these organs to turn black. If it involves the cartilage, it can lead to exfoliation of the subchondral bone.

First of all, back stiffness and pain are related to many reasons. I believe that through the above introduction, many patients with this symptom also understand what the causes are? After a comprehensive understanding, in order to prevent this disease from seriously affecting your physical health and life, it is best to choose to go to a large hospital for examination, and then through treatment, I believe you can recover as soon as possible.