The role of metronidazole

Metronidazole is a very common drug. It is very effective in preventing and treating infections caused by anaerobic bacteria, especially meningitis caused by digestive tract and respiratory tract infections. Metronidazole tablets are also a common drug. They are very good for treating some diseases of the abdominal cavity and female reproductive system, especially gynecological diseases in women, such as Trichomonas vaginitis. Let's take a look at the effects of metronidazole.

Metronidazole has many functions and is widely used. It has also made great breakthroughs in medical treatment, especially for the treatment of hyperlipidemia. When taking this medicine, you should understand some instructions and stop taking it in time if there are adverse reactions.

"Metronidazole" is another name for "metronidazole". Metronidazole (referring to this entry) is used to treat intestinal and extraintestinal amebiasis (such as amoebic liver abscess, pleural amebiasis, etc.). It can also be used to treat vaginal trichomoniasis, balantidiasis, cutaneous leishmaniasis, guinea worm infection, etc. It is also widely used in the treatment of anaerobic infections

Indications

【Pharmacokinetics】

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【Indications】

Metronidazole files are often used to treat acute periodontitis and local alveolar swelling and other dental discomforts.

【Usage and Dosage】

1. Common dosage for adults

(1) Intestinal amebiasis: 0.4-0.6 g each time, 3 times a day, for a course of 7 days; extraintestinal amebiasis: 0.6-0.8 g each time, 3 times a day, for a course of 20 days

(2) Giardiasis: 0.4 g each time, 3 times a day, for a course of 5 to 10 days

(3) Guinea worm disease: 0.2 g each time, 3 times a day, for 7 days

(4) Balantidiasis: 0.2 g each time, twice a day, for 5 days

(5) For cutaneous leishmaniasis, 0.2 g each time, 4 times a day, for a course of 10 days. Repeat the course after an interval of 10 days.

(6) For trichomoniasis, take 0.2 g each time, 4 times a day, for a course of 7 days. You can also use suppositories at the same time, insert 0.5 g into the vagina every night for 7 to 10 days.

(7) For anaerobic infection, take orally 0.6-1.2 g per day, divided into 3 doses, for a course of 7-10 days.

2. Common dosage for children

(1) For amebiasis, take 35-50 mg/kg of body weight orally three times a day. A course of treatment is 10 days.

(2) For giardiasis, take 15-25 mg/kg of body weight orally three times a day for 10 consecutive days. The dose for treating dracunculiasis, balanitis, and trichomoniasis is the same as that for giardiasis.

(3) For anaerobic infection, take orally 20-50 mg/kg per day based on body weight.

【Adverse Reactions】

Adverse reactions occur in 15% to 30% of cases, with gastrointestinal reactions being the most common, including nausea, vomiting, loss of appetite, and abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, occasional paresthesia, limb numbness, ataxia, multiple neuritis, etc., and high doses can cause convulsions. A small number of cases develop urticaria, flushing, itching, cystitis, dysuria, metallic taste in the mouth, and leukopenia, all of which are reversible and recover on their own after stopping the drug.

4. Notes

【Taboo】

Contraindicated in patients with active central nervous system disorders and blood diseases

【Notes】

(1) Interference with diagnosis: The metabolites of this product can make urine dark red.

(2) The dosage should be reduced for patients with existing liver disease. The drug should be discontinued if movement disorders or other central nervous system symptoms occur. A white blood cell count should be performed before repeating a course of treatment. For patients with anaerobic infection and renal failure, the dosing interval should be extended from 8 hours to 12 hours.

(3) This product can inhibit alcohol metabolism. You should abstain from alcohol during medication. Drinking may cause abdominal pain, vomiting, headache, etc.

(4) This product has a strong irritation to the stomach and should be taken after meals

Everyone should know the effects of metronidazole. This drug is widely used in the medical field. Everyone should also understand the dosage of metronidazole. Some people will have many adverse reactions when taking this drug, such as nausea, vomiting, anorexia, and headache. A small number of patients will have symptoms of measles and difficulty urinating, so the drug should be stopped in time.

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