Is high glutamyl transpeptidase a sign of liver cancer? Don’t necessarily pay attention to these three major hazards

Does high glutamyl transpeptidase mean liver cancer? γ-Glutamine transpeptidase (γ-GT) is widely distributed in human tissues, with the highest concentration in the kidney, followed by the pancreas and liver. In the embryonic period, it is most abundant in the liver. In the liver, it is mainly distributed in the hepatic cytoplasm and intrahepatic bile duct epithelium. In normal human serum, γ-GT mainly comes from the liver. The normal value is 3-50μ/L (γ-glutamyl para-nitrosamine method). This enzyme is only slightly or moderately elevated in acute hepatitis, chronic active hepatitis and decompensated cirrhosis. However, in obstructive jaundice, this enzyme flows back into the blood due to excretion disorders. In primary liver cancer, this enzyme is synthesized in the liver. Hyperactivity can cause a significant increase in blood transpeptidase, even up to 10 times the normal level. ν-GT is also significantly elevated in alcoholics, which helps diagnose alcoholic liver disease. In acute hepatitis, ν-GT drops to normal later than transaminase. If ν-GT continues to rise, it indicates a transition to chronic liver disease. In chronic liver disease, especially cirrhosis, a persistently low ν-GT value indicates a poor prognosis. If it is caused by pathological reasons, r-glutamyl transpeptidase will increase exponentially; if it is slightly elevated, it may be due to drinking, staying up late, fatigue, taking medication, etc.

The dangers of high r-glutamyl transferase
1. Indication of viral hepatitis: In acute viral hepatitis, the liver cells adjacent to the necrotic area synthesize excessive amounts of hepatic enzymes, causing elevated serum glutamyl transpeptidase. In chronic active hepatitis, the glutamyl transpeptidase [2] test value is often 1 to 2 times higher than the normal value of glutamyl transpeptidase. If it remains elevated for a long time, there may be a tendency for liver necrosis.
2. Indication of hepatobiliary disease: When the intrahepatic or extrahepatic bile duct is obstructed, the excretion of glutamyl transpeptidase is blocked and refluxes into the blood with bile, resulting in elevated serum glutamyl transpeptidase.
3. Predicts fatty liver: Glutamyl transpeptidase is often elevated in patients with fatty liver, but in general, serum glutamyl transpeptidase activity in nutritional fatty liver is usually no more than twice the normal value.
In addition to prevention of causes such as drinking, staying up late, fatigue, and taking medication, treatment mainly focuses on the treatment of the corresponding diseases.