Does high glutamyl transpeptidase mean liver cancer? γ-Glutamine transpeptidase (γ-GT) is widely distributed in human tissues, with the highest concentration in the kidney, followed by the pancreas and liver. In the embryonic period, it is most abundant in the liver. In the liver, it is mainly distributed in the hepatic cytoplasm and intrahepatic bile duct epithelium. In normal human serum, γ-GT mainly comes from the liver. The normal value is 3-50μ/L (γ-glutamyl para-nitrosamine method). This enzyme is only slightly or moderately elevated in acute hepatitis, chronic active hepatitis and decompensated cirrhosis. However, in obstructive jaundice, this enzyme flows back into the blood due to excretion disorders. In primary liver cancer, this enzyme is synthesized in the liver. Hyperactivity can cause a significant increase in blood transpeptidase, even up to 10 times the normal level. ν-GT is also significantly elevated in alcoholics, which helps diagnose alcoholic liver disease. In acute hepatitis, ν-GT drops to normal later than transaminase. If ν-GT continues to rise, it indicates a transition to chronic liver disease. In chronic liver disease, especially cirrhosis, a persistently low ν-GT value indicates a poor prognosis. If it is caused by pathological reasons, r-glutamyl transpeptidase will increase exponentially; if it is slightly elevated, it may be due to drinking, staying up late, fatigue, taking medication, etc. The dangers of high r-glutamyl transferase |
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