A brief analysis of the manifestations of osteosarcoma in women

The most common symptom of osteosarcoma patients is pain, which mostly occurs in young people and has a great impact on patients and their families. Many people have paid a great price for this. So how should osteosarcoma be avoided? What are the manifestations of osteosarcoma in women? Everyone is curious about this, so here we introduce the common manifestations of osteosarcoma.

1. Telangiectatic osteosarcoma, accounting for only 5%, is a highly malignant osteosarcoma. The patient has a short medical history, the tumor grows rapidly, and the X-ray shows osteolytic destruction. The gross specimen shows a spindle-shaped swelling, with thinning of the cortex, reddish-brown blood sinusoids, and tumor tissue on the sinusoid wall. Microscopically: malignant tumor cells and tumorous bone-like tissue exist in the blood-filled cavity, and X-ray and low-power microscopic observations are similar to aneurysmal bone cysts.

2. Small round cell osteosarcoma, with high malignancy and poor prognosis. X-rays show osteolytic destruction, grayish-white fish-like appearance to the naked eye, and microscopically composed of a large number of densely packed small round cells, which are round, oval, or short spindle-shaped, with unclear capsule boundaries, small cell mass, different nuclei, unclear nucleoli, and connective tissue separating cells. Tumorous bone-like tissue can be seen between cells.

3. Fibrous histiocytic osteosarcoma, the age of onset is usually after the third age group. X-rays show osteolytic destruction involving the ends of long bones, sometimes with cotton-like or cloud-like shadows. There are rarely typical periosteal reactions. Microscopically, there are characteristic pleomorphic spindle cells and multinucleated giant cells. Many multinucleated giant cells have odd-shaped nuclei, sometimes with an inflammatory background, characteristic spoke-shaped or spiral-shaped arrangements, and sometimes cells may have a few protrusions. Like all osteosarcomas, pleomorphic cells are diffusely arranged, and typical tumor-like bone and bone-like tissue formation can also be seen under the microscope.

4. Intramedullary well-differentiated osteosarcoma is a low-grade osteosarcoma with an older age of onset and mild symptoms. It is similar to fibrous dysplasia on X-ray, but with unclear boundaries and invades or penetrates the cortex. The gross specimen is gray-white rubber-like, and under the microscope, there are a large number of proliferating fibroblasts. These cell nuclei are deeply stained and have different morphologies. Different amounts of tumorous bone-like tissue and bone can be seen between cells.

5. Multicentric osteosarcoma. Modern scholars believe that osteosarcoma is a systemic disease, most of which are composed of single lesions and tiny lesions that cannot be detected by modern detection methods. Multicentric osteosarcoma is rare, with multiple tumor lesions appearing at the same time, while adult patients first have a single lesion and then gradually multiple lesions. They are prone to long bones, and X-rays show osteoblastic type, AKP is very high, the prognosis is poor, and there is usually no visceral metastasis.

In short, the treatment of osteosarcoma requires not only timely diagnosis, but also different treatment plans according to different types. In severe cases, amputation may be required. Therefore, once osteosarcoma is discovered, it is necessary to diagnose its type to avoid delaying treatment.