Is bile duct cancer generally hereditary?

Due to various reasons, in modern society, cancer has entered the lives of many people like an uninvited guest, which has forced us to pay more attention to cancer. Biliary duct cancer is a type of cancer, so is bile duct cancer generally hereditary? Let's take a closer look at this issue.

The bile duct is one of the important organs of the human body. With the continuous advancement of medical technology, more and more people are diagnosed with bile duct diseases. Among these bile duct diseases, the most serious one is bile duct cancer. How does bile duct cancer come about? Will it be inherited to the next generation? This is also a question that many bile duct cancer patients want to know. Let me introduce to you whether bile duct cancer will be inherited to the next generation.

According to European scholars, the genetic similarity between concurrent hepatocellular carcinoma and cholangiocarcinoma (HCC-CC) and cholangiocarcinoma (CC) is higher than that between hepatocellular carcinoma, and changes may occur in the common carcinogenic pathways of the two.

The researchers selected 9 patients with cholangiocarcinoma, 15 patients with concurrent hepatocellular carcinoma-cholangiocarcinoma, and 3 patients with solitary hepatocellular carcinoma and cholangiocarcinoma lesions ("collision tumors") and compared them with 137 previously characterized HCC patients by detecting loss of heterozygosity (LOH), p53, and β-catenin mutations using 400 microsatellite markers.

Results: TP53 gene mutations were found in 6 patients with cholangiocarcinoma and concurrent hepatocellular carcinoma-cholangiocarcinoma. Two patients with collision tumors had CTNNB1/β-catenin, but no patients with cholangiocarcinoma or concurrent hepatocellular carcinoma-cholangiocarcinoma had mutations.

Through the introduction above, I believe that everyone now has some understanding of whether bile duct cancer will be inherited to the next generation. Yes, bile duct cancer has certain genetic factors, but this cannot prove that bile duct cancer will definitely be inherited to the next generation. If you do not come into contact with these causes of bile duct cancer, you will not suffer from bile duct cancer.