Causes of osteosarcoma

As we all know, osteosarcoma is difficult to cure and prone to recurrence, so what are the causes of osteosarcoma? Let me first introduce to you what osteosarcoma is. Osteosarcoma, also known as osteogenic sarcoma, is a malignant bone tumor that develops from the mesenchymal cell line. Because the tumor directly or indirectly forms tumor bone-like tissue and bone tissue during the cartilage stage, the tumor grows rapidly. After understanding osteosarcoma, let's learn about the causes of osteosarcoma.

1. Causes

Modern medicine has not yet fully understood the cause of this disease. Some people point out that radioactive isotope radium and traumatic stimulation are inducing factors. Lesions occurring in long bones are mostly located in the epiphysis, and a few in the middle of the shaft. The tumor rapidly develops along the medullary cavity, spreading to the epiphyseal end on the one hand, and occasionally spreading to the shaft on the other hand. In addition, the tumor also rapidly develops outward, invading the Hasserian system in the cortical bone and causing vascular nutritional disorders. The cortical bone is then destroyed, and the tumor quickly reaches under the periosteum and invades the adjacent muscle tissue outward.

In addition, it is related to genetics, exposure to radioactive substances, viral infection, etc. It can also be secondary to osteitis deformans and fibrous dysplasia of bone. Some cases are caused by the malignant transformation of other benign tumors.

Pathogenesis

The pathogenesis of this disease is not very clear. Its histological feature is that the proliferating spindle-shaped tumor cells directly produce osteoid matrix or immature bone, but its hair type and histological characteristics are different, which have been described in the overview of this article.

Osteosarcoma originates from primitive progenitor cells, which have multipotential characteristics and can differentiate into bone, cartilage and fiber. Therefore, in addition to malignant osteoblasts, osteosarcoma also has chondroblasts and fibroblasts. According to the amount of these three cell components, central osteosarcoma can be divided into osteoblast type (osteoblastic type), chondroblast type (cartilage type) and fibroblast type (fibroblastic type).

The above is what we want to introduce to you about the causes of osteosarcoma. We hope it will be helpful for you to prevent osteosarcoma.