Is creatinine 500 serious?

In the medical field, the levels of different hormones or secretions in the human body are defined by relevant standards. If the difference from the standard value is too large, it often indicates that an abnormal condition has occurred in the human body and should not be taken lightly. As we all know, creatinine mainly refers to toxins produced by the metabolism of human muscle tissue. The creatinine content is also closely related to the renal function of the human body. So when the creatinine index is 500, is it a sign of severe kidney disease?

High creatinine means that the creatinine value is higher than the normal value. Creatinine includes blood creatinine and urine creatinine, but blood creatinine is a more meaningful measure of renal function. Therefore, high creatinine generally refers to high blood creatinine. The normal value of blood creatinine is measured by different standards in different hospitals. Generally speaking, the normal value of blood creatinine is 44-133μmol/L. When blood creatinine exceeds 133μmol/L, it means that the kidneys are damaged and renal insufficiency or renal failure has occurred. (133μmol/L and above is the inflammatory damage stage, 186μmol/L is the renal function damage stage, and 451μmol/L is the renal failure stage).

Causes

Creatinine is a product of human muscle metabolism. In human muscles, creatine is mainly converted into creatinine through irreversible non-enzymatic dehydration reaction, then released into the blood and excreted in urine. Therefore, the reason why blood creatinine is high is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecule that can be filtered through the glomerulus and is rarely reabsorbed in the renal tubules. Almost all of the creatinine produced in the body daily is excreted in the urine and is generally not affected by urine volume.

Symptoms of high creatinine

Symptoms of high creatinine levels include:

1. Edema often starts from the eyelids (some patients start from the lower limbs), and severe cases may spread to the whole body and even cause pleural effusion and ascites.

2. Hypertension is one of the manifestations of high creatinine levels.

3. Frequent urination (many times), urgency (inability to hold urine), and pain when urinating (pain in the lower abdomen and urethra during urination).

4. Most low back pains are dull pains, but surgical diseases may cause severe colic.

5. Hematuria means that there are blood cells in the urine, or the test shows positive occult blood (with a plus sign).

6. Polyuria refers to urine output exceeding 2500 ml per day and night.

7. Oliguria or anuria Less than 400 ml per day and night is called oliguria, and less than 100 ml is called anuria.

8. Excessive foam in the urine may be a sign of increased urine protein. A positive urine protein test result is reliable evidence of increased urine protein.