Astemizole and Chlorpheniramine_The difference between Astemizole and Chlorpheniramine

Many drugs have the same effect, so people have multiple options when treating diseases. When doctors prescribe medicine to treat diseases, they will choose medicines with better therapeutic effects based on the patient's physical condition, because some medicines may have an impact on the patient's body or other medicines he or she is taking. Let’s learn about the differences between Astemizole and Chlorpheniramine.

1. Which is better, Astemizole or Chlorpheniramine?

Astemizole is a potent and long-acting histamine H1 receptor antagonist without central sedation and anticholeretic effects. Because of its long-lasting effect, a single daily application can control allergy symptoms for 24 hours. Receptor binding studies have shown that this product can provide complete peripheral H1 receptor binding rate at pharmacological doses. Since it does not pass the blood-brain barrier, it has no effect on central H1 receptors. Used to treat perennial and seasonal allergic rhinitis, allergic conjunctivitis, chronic urticaria and other symptoms and signs of allergic reactions.

The main therapeutic ingredient of chlorpheniramine is chlorpheniramine maleate, which is a first-generation antihistamine. Chlorpheniramine is one of the strongest antihistamines. Its sedative effect is weaker than that of promethazine, and it also has certain anticholine effects. Suitable for skin allergies: urticaria, eczema, dermatitis, drug rash, pruritus, neurodermatitis, insect bites, solar dermatitis, and can also be used for allergic rhinitis, drug and food allergies. The main adverse reactions are drowsiness, thirst, polyuria, sore throat, sleepiness, weakness, palpitations, skin ecchymosis, and bleeding tendency. Therefore, chlorpheniramine is very effective in treating allergic rhinitis.

It can be seen from this that chlorpheniramine and astemizole have certain similarities in their efficacy, and both have obvious therapeutic effects on diseases such as allergies, but the effect of chlorpheniramine is slightly better.

2. Precautions for taking Astemizole

1. Patients with severe liver dysfunction should use this product under the guidance of a doctor.

2. Use with caution during pregnancy and lactation.

3. The use of this product should be discontinued about 48 hours before the skin test, because antihistamines can prevent or reduce the occurrence of positive reactions in skin tests.

4. People who are allergic to this product are forbidden to use it, and those with allergic constitution should use it with caution.

5. It is forbidden to use this product when its properties change.

6. Please keep this product out of reach of children.

7. Children must use this product under adult supervision.

8. If you are using other medicines, please consult your physician or pharmacist before using this product.

9. The safety and efficacy of this product for children under 6 years old have not been determined yet. Please consult your doctor or pharmacist.

10. Patients with impaired liver and kidney function should reduce the dosage. It is recommended to take 10 mg once every 2 days or use under the guidance of a doctor.

11. Because the plasma concentration of elderly patients after taking the drug is higher than that of healthy people, elderly patients need to pay close attention to the occurrence of adverse reactions when using this product for a long time.

12. Overdose of this product (40-180 mg) in adults may cause drowsiness, arrhythmia, and headache. Once the above symptoms occur, give symptomatic and supportive treatment immediately. Treatment involves inducing vomiting, followed by activated charcoal to absorb any unabsorbed drug. If vomiting is unsuccessful, gastric lavage with normal saline and catharsis are performed to dilute the drug concentration in the intestine. Hemodialysis cannot remove loratadine, and it has not been determined whether peritoneal dialysis can remove this product.